Science: COVID19 neutral antibodies show therapeutic potential

, June 16, 2020 /--- PRNewswire/ -- In a recent study, researchers at the Scripps Institute tested animal and human cells and found that antibodies in the blood of recovered COVID-19 patients provided strong protection against SARS-CoV-2the results, published recently in the journal Science, laid the groundwork for clinical trials and additional tests on antibodiesat present, the treatment or vaccine development for severe COVID-19 is the most important health problem in the worldGlobally, nearly 8 million people have tested positive for SARS-CoV-2 infection, and 400,000 people have died, and the number of new infections is still rising every day(photo:one way to address the new virus threat is to identify antibodies in the blood of recovered patients that have the ability to neutralise the virusauthors Rogers et altook blood samples from patients recovering from mild to severe COVID-19At the same time, Scripps Research and IAVI scientists have collaborated to develop cells that express ACE2In a preliminary set of experiments, the team tested whether blood samples from patients could bind to the virus and prevent infected cellsAfter, the scientists isolated more than 1,000 different antibody-producing B-cells, and obtained a sequence of antibody genes from those B cells so that antibodies could be produced in the labBy sifting through the antibodies individually, the team identified several candidates that could block the virusall of this work - including the development of cell and animal infection models, as well as studies of the location of target antibodies and viral bindings - was done in less than seven weeksIf further animal safety trials and human clinical trials go well, it could be used in clinical practice as early as January next year, the researchers said(Bio Valley Bioon.com)source: Super-potent human antibodies against coVID-19 in animal tests
original source: Thomas F Rogers et al.
Isolation of the potent SARS-CoV-2 neutralizing anti anti and protection from disease in a animal small model model.
Science 15 Jun 2020, DOI: 10.1126/science.abc7520, science.sciencemag.org/content .. 6/15/science.abc7520