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    Home > Biochemistry News > Biotechnology News > Science cover article: Generating CAR-T cells in vivo to treat heart damage

    Science cover article: Generating CAR-T cells in vivo to treat heart damage

    • Last Update: 2022-01-26
    • Source: Internet
    • Author: User
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    Preparation of CAR-T cells in vivo

    Cardiac fibrosis is fatal


    Rurick et alAn immunotherapy strategy was designed to generate transient chimeric antigen receptor (CAR) T cells capable of recognizing cardiac fibrotic cells (see Gao and Chen)


    We have developed a therapeutic approach to generate transient anti-fibrotic chimeric antigen receptor (CAR) T cells in vivo by delivering modified messenger RNA (mRNA) in T cell-targeting lipid nanoparticles (LNPs)


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