SCIENCE: Circulating tumor cells point to tumor metastasis through ribosome protein
-
Last Update: 2020-05-29
-
Source: Internet
-
Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit
www.echemi.com
Circulating tumor cells (CTCs) fall off from the primary tumor to the bloodstream, but only a small fraction of them are metastasizedrecently, researchers performed a genome-wide CRISPR-in-the-genome-wide CRISPR activation screening in breast cancer patients to determine the genes that promote distant metastasis in miceGenes that encode ribosome proteins and translation regulators were enriched in this screeningencode sepsis of RPL15, the component of large ribosome subunit, increases the metastatic growth of multiple organs, and selectively enhances the translation of other ribosome proteins and cell cycle regulatorsRNA sequencing of freshly isolated CTCs from breast cancer patients, the researchers found a subset of strong ribosome and protein synthesis characteristics that express proliferation and epithelial markers and are associated with poor clinical outcomestherefore, the treatment of this invasive subset of CTCs may be worth exploring because it is a potential inhibitor of metastatic progression
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
