Science: Break the conventional wisdom!

Neutrophils are among the first responders of our immune system

In a new study, researchers from the Max Planck Institute of Immunobiology and Epigenetics in Germany deciphered the basic biological characteristics of neutrophil swarming and found that these cells also Evolve an inherent molecular program to limit their cluster activity by myself

The body is protected by the skin and other barriers, which can well resist the invasion of pathogens

Cluster to fight infection

Tim Lmmermann, the corresponding author of the paper, said, "Neutrophils are very effective in hunting bacteria

The subtle difference between host protection and tissue destruction

However, this form of beneficial inflammation can also be excessive, leading to massive tissue destruction

In the field of inflammation and infection research, neutrophil clustering is still a relatively new topic, and its basic mechanism has just begun to be explored

Lmmermann said, "We have discovered a molecular break mechanism in neutrophils: once they sense the high concentration of swarm attractants that accumulate in a larger population of neutrophils.

The self-organization process of neutrophil population, picture from Science, 2021, doi: 10.

An internal start-stop system that optimizes bacteria removal

In view of the start-stop system found in neutrophils, the Lmmermann team reassessed the current view on how neutrophils navigate through tissues to effectively eliminate bacteria

Lmmermann explained, “It’s shocking that we have made the opposite discovery

With these results, the Lmmermann team paved the way for a better understanding of neutrophil biology, which is critical to the immune host’s defense against bacteria and may help develop new treatments in the future

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BrianaL.