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Figure: Atomic structure of the Omicron variant spike protein (purple) bound to the human ACE2 receptor (blue)
Source: UBC School of Medicine
"Understanding the molecular structure of the viral spike protein is important as it can help us develop more effective therapeutic Omicron and related variants in the future," said lead author Sriram Subramaniam, Ph.
The spike protein located on the outside of the coronavirus enables SARS-CoV-2 to enter human cells
Structural analysis revealed that some mutations (R493, S496 and R498) established new salt bridges and hydrogen bonds between the spike protein and the human cell receptor ACE2
Dr Subramaniam said: "Overall, the findings suggest that Omicron has greater binding affinity than the original virus, at levels more similar to what we have seen with the Delta virus variant
The researchers conducted further experiments showing that the Omicron spike protein exhibited increased antibody evasion
Notably, Omicron evaded less immunity from vaccines than immunity from natural infection in unvaccinated patients
As a next step, Dr.
"An important focus of our team is to better understand the binding of neutralizing antibodies, as well as therapeutics that are effective across the full spectrum of variants, and how these approaches can be used to develop anti-variant therapies
article title
SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion
