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The interaction of transcription factors (TFs) with DNA is fundamental to gene regulation, and different cell types are defined by unique TF binding profiles
cfDNA has the potential to map tumor epigenomes in real time and therefore can help reveal the regulation
Recently, a research team from the University of Colorado in the United States mapped the TF binding map of individual binding sites in plasma cfDNA, defining cfDNA characteristics
The article was published on Science Advances
ChIP-seq and CUT&RUN methods applied to cell line and tissue samples are standard methods for detecting TFBS in the genome
Figure 1.
Figure 2: Lymphatic/myeloid-derived cfDNA contains a hematopoietic TF footprint
Figure 3: The ER+ breast cancer xenograft model is able to recognize pure tumor cfDNA imprinting
Figure 6: Tissue-specific TFBSs enable detection of disease states
Resources:
Transcription factor–nucleosome dynamics from plasma cfDNA identifies ER-driven states in breast cancer.
