Science Advances Jiao Yuling Group and Mathematical Center Zhang Lei..

Morphogenesis first requires the establishment of key gene and protein distribution patterns

On June 8, 2022, Peking University School of Life Sciences/Joint Center for Life Sciences/Center for Quantitative Biology/State Key Laboratory of Protein and Plant Genetic Research Jiao Yuling's group and Zhang Lei's group from the International Center for Mathematics/Center for Quantitative Biology collaborate in Science Advances Published a research paper titled "Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis" (DOI:10.

Both leaf primordia and flower primordia express REVOLUTA (REV) on the adaxial surface near the meristem, and express KANADI1 (KAN1) on the complementary abaxial surface

Figure 1.

This study first simulates the developmental pattern that possible regulatory mechanisms can form

Figure 2.

The study further validated the predicted regulation in Arabidopsis thaliana and found that MONOPTEROS (MP), a key transcription factor of the auxin signaling pathway, directly activates the expression of REV and KAN1

The above research not only answers the maintenance mechanism of the proximal-distal axis genes in leaves and flower primordia, but also theoretically proposes a new model for the homeostasis maintenance of developmental pattern: the simultaneous activation of mutually antagonistic gene expression by upstream factors can form a stable developmental pattern

Associate researcher Guan Chunmei from the Institute of Genetics and Development, Chinese Academy of Sciences and Qiao Lingxia, a 2020 Ph.