science advance: Can cancer cells manipulate the nervous system?

Breast cancer is one of the most common cancers in women.

Breast cancer is one of the most common cancers in women.

A recent study published in Science Advances found an innovative breast cancer treatment based on analgesic nanoparticles that target the nervous system

In this study, the researchers found that triple-negative breast cancer cells (4T1) have a mutual relationship with the nerve cells around them: signal transmission between triple-negative breast cancer cells (4T1) and neurons involves stimulating neuron growth Secretion of cytokines

In this study, the researchers found that triple-negative breast cancer cells (4T1) have a mutual relationship with the nerve cells around them: signal transmission between triple-negative breast cancer cells (4T1) and neurons involves stimulating neuron growth Secretion of cytokines

Based on these findings, researchers have developed a treatment method that uses nerve cells to target tumors

Based on these findings, researchers have developed a treatment method that uses nerve cells to target tumors

They encapsulated drug molecules in nanoparticles

In vitro, 100-nanometer nanoparticles are easily absorbed by primary neurons and trafficked from the neuronal body and along axons

In vitro, 100-nanometer nanoparticles are easily absorbed by primary neurons and trafficked from the neuronal body and along axons

The results of the experiment found that bupivacaine inhibited the growth of neurons and signal transmission with cancer cells, inhibiting the vitality of cancer cells

The results of the experiment found that bupivacaine inhibited the growth of neurons and signal transmission with cancer cells, inhibiting the vitality of cancer cells

Maya Kaduri said that the anesthetic particles move in the blood but will not penetrate healthy tissues

Maya Kaduri said that the anesthetic particles move in the blood but will not penetrate healthy tissues

This is a very concentrated and precise treatment method that allows us to inject large amounts of anesthetic into the body, because there is no need to worry about it harming the health and important areas of the nervous system

In general, the results of the study indicate that reducing the involvement of nerves in tumors is important for the treatment of cancer

Reference: Maya Kaduri et al, Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases,Science Advances(2021).
DOI: 10.
1126/sciadv.
abj5435 .
Www.
science.
org/doi/10.
1126/sciadv.
abj5435 Science Advances DOI: 10.
1126/sciadv.
abj5435

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