 Home > Active Ingredient News > Antitumor Therapy > Science: Major development of CAR-T cells that recognize the expression level of protein antigens on the surface of cancer cells, which is expected to be used in the treatment of solid tumors

Science: Major development of CAR-T cells that recognize the expression level of protein antigens on the surface of cancer cells, which is expected to be used in the treatment of solid tumors

 Last Update: 2021-04-21
 Source: Internet
 Author: User

Tags

comfortable car seats

genetic engineering

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

March 24, 2021 //---In cancer immunotherapy, cells in the patient's own immune system are activated to attack cancer cells.

In CAR-T cell therapy, T cells are extracted from patients for genetic modification: using viral vectors to deliver chimeric antigen receptors (CAR) to T cells to form CAR-T cells to better recognize and kill cancer cell.

Electron micrograph of human lymphocytes.

In a new study, researchers from the University of California, San Francisco and the University of Helsinki in Finland found a solution for CAR-T cells for the treatment of solid tumors: they discovered a new kind of anti-CAR-T cell The method of programming allows them to kill only cancer cells, while letting go of healthy cells that have the same protein markers as cancer cells.

This new technology based on ultra-sensitive identification of HER2 cells is under further study

HER2 is a characteristic protein of breast cancer, ovarian cancer and abdominal cancer.

A new CAR-T cell engineering technology developed by these researchers is based on a two-step identification process for HER2-positive cells.

The co-author of the paper and Professor of Virology at the University of Helsinki, Kalle Saksela, said, “Our solution requires preliminary identification of cancer-related surface structures.

Further application research of this technology is already in progress.

Mäkelä said, "We are very excited about these results, and we are currently developing this technology so that it can be used to treat ovarian cancer.

Reference:

Reference:

Rogelio A.
Hernandez-Lopez et al, sciencemag.
org/content/371/6534/1166" target="_blank">T cell circuits that sense antigen density with an ultrasensitive threshold , Science (2021).
DOI: 10.
1126/science.
abc1855.

A leap forward in research on CAR T cell therapy
https:/ /medicalxpress.
com/news/2021-03-car-cell-therapy.
html sciencemag.
org/content/371/6534/1166" target="_blank">T cell circuits that sense antigen density with an ultrasensitive threshold

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.