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The researchers report that an amino acid change in the transketolase-like 1 (TKTL1) protein may have given modern humans an advantage over older contemporaries such as Neanderthals, thereby promoting neocortical neurogenesis
The outer region of the cerebral cortex—the neocortex—is an evolved, advanced brain structure responsible for cognitive abilities
Previous research has shown that differences in neural progenitor cell populations can lead to changes in the size and shape of the neocortex in
In human fetal neocortical tissue and brain organoids, disruption of hTKTL1 expression or replacement of hTKTL1 with ancient variants leads to a decrease