Sci Transl Med: Identify key proteins that control the body's biological clock

May 12, 2020 /PRNewswire2020 (

BioON/ -- In a recent study published in the international journal
science, Science Medicine , scientists from the Beijing Institute of Life Sciences and other institutions in China found a special protein that maintains the biological clock in mice image source: Zhancong Xu's circadian rhythm clock/biological clock is the biological process of regulating machine function, most famously the sleep cycle, but unfortunately, despite the efforts of scientists, they still don't know how the "biological machine" involved in the biological clock process works, the researchers solved the study In the paper, researchers screened 10,000 experimental drugs to find drugs that could have a direct effect on the biological clock, and finally found a compound called cordycepin, a natural compound found in a rare fungus that can only be tested in a synthetic form of the compound because of its high price The researchers then began to reveal the molecular mechanisms by which the insects affected the biological clocks of mice, and in the lab they simulated mice traveling in different parts of the world by changing the mice's light and dark schedules; in some cases, they pushed the mice up eight hours and, in other cases, eight hours back In both cases, the researchers gave mice a dose of pyrobutts, and then monitored them to see how the mice changed their sleep cycles to adapt to the new environment, and the researchers found that the study group took only four days to change compared to the normal eight days of the control group After a more in-depth study of synthetic pyroplasm, the researchers found that it binds to an enzyme called RUVBL2, which affects the transcription of genes that control the biological clock, so that pyroplasm can turn on or off such transcriptions, and the researchers also note that RUVBL2 is more likely to exhibit higher levels in certain parts of the mouse brain, which react to light signals entering the eye (biovalleybioon.com) Original Origin: Dapeng Ju, Wei Zhang, Jiawei Yan, et al.
Chemical perturbation reveal that RUVBL2 regulate the circadian phae in mammal , Science Tranlation al Medicine (2020) DOI: 10.1126/citranlmed.aba0769