SCI Rep: Chinese scholars have found a new target of anti-cancer, controlling the life gate of glioma!

September 18, 2018 / BIOON / - researchers from the Virginia Tech Carilion Research Institute (vtcri) say a gene involved in human biological rhythms may be a potential therapeutic target for fatal glioma The new discovery, published in scientific reports recently, is called "casein kind 1 epsilon regulations glioblastoma cell survival" The study points out that a special gene can obviously maintain the survival of tumor cells, although the gene is usually related to biological rhythm Photo source: scientific reports "the world is sparing no effort to find a way to treat gliomas, but no one has found that this gene is one of the target genes to treat gliomas." The study's author, Shi Sheng, an associate professor of vtcri, said his team had identified the gene from 20 suspected genes "We have found that inhibition of this gene may inhibit the ability of tumor stem cells to self renew and differentiate into glioma cells, which are considered to be one of the characteristics of such intractable cancers." Said Sheng "Although more research is needed before a new treatment can be designed, our early basic research is promising." Sheng said that patients with glioma all over the world are in urgent need of new treatment Most patients survive less than 15 months after diagnosis, 90% of patients survive more than 2 years will relapse, and recurrent gliomas usually can not be operated on The disease causes almost half of brain cancer deaths Sheng said that even if only a few hundred glioma stem cells survive after surgery, radiotherapy and chemotherapy, the cancer will recur But in their experiments with cancer cells and mouse models, the researchers found that when an enzyme produced by a member of the casein kinase 1 family was inhibited, the proliferation of glioma stem cells would stop, and tumor growth in mice would also be inhibited The researchers also found evidence that the enzyme is responsible for regulating the rate of self-renewal of glioma stem cells, rather than controlling differentiation "Inhibition of this gene can effectively kill glioma stem cells." Said Sheng Sheng and his colleagues also evaluated two commercially available drugs that inhibit casein kinase 1, and found that one of them has the potential to be further studied as a brain glioma stem cell inhibitor Reference: Zhi Sheng et al Casein King 1 epsilon regulations glioblastoma cell survival Scientific reports (2018) Doi: https://doi.org/10.1038/s41598-018-31864-x