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Image: Wrinkles appear on the surface when force is applied to the silicone substrate
Image credit: Tokyo Metropolitan University
Researchers at Tokyo Metropolitan University have developed a method to characterize the forces generated by contracting myotubes, the precursors of skeletal muscle fibers, combining electrical stimulation and analysis of wrinkles on silicone substrates
Muscle atrophy, the degeneration of muscle tissue, can have devastating effects on quality of life and is known to affect longevity
But the reality is that treatments for muscle wasting are still very limited
Now, a research team led by Associate Professor Yasuko Mabe at Tokyo City University has come up with a simple way to directly measure the strength of myotubes
Using known atrophic (weaker) and hypertrophic (stronger) myotubes, they found that their new "strength index" was more sensitive to muscle strength than existing measures such as muscle mass and myosin heavy chain (MHC) ) protein expression
This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Scientific Research Assistance Fund (B) (grant number JP 17H02159) in the field of sports science, the Tokyo Medical University Innovative Research Project Strategic Research Fund, and the Tokyo Metropolitan Government Advanced Research Fund (R2- 2) support
