SCI Immunol: scientists found the first cell scorch inhibitor, or it can treat inflammatory diseases

August 26, 2018 / bioin / - inflammatory cell death disorder is the main cause of many inflammatory diseases Cell Scorch is a highly inflammatory cell death process, which will use the holes generated in the cell to disrupt the electrolyte balance of the cell, leading to cell death Gasdermin D is the pore forming effector protein in the process of cell scorching, which can control the cell membrane cracking and the release of highly inflammatory molecules (such as interleukin-1 β), which will aggravate the over activation of innate immune response But so far, no drugs have been found that can disrupt the charring of cells Photo source: Science immunology recently, researchers from the medical school of Case Western Reserve University and Cleveland Clinic found that necrosulfonamide is a direct chemical inhibitor of gasdermin D, which can directly combine with gasdermin D, thus inhibiting cell scorch Relevant research results were published in science immunology recently, entitled "chemical disruption" of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis”。 In a sepsis animal model, the researchers found that necrosulfonamide can effectively inhibit the death of pyrolytic cells This suggests that gasdermin D inhibitors may be effective in the treatment of inflammatory diseases Reference materials: rathkey et al, chemical disruption of the psychological pore forming protein gasdermin D inbits informational cell death and sepsis, science Immunology (2018) Doi: 10.1126/scientific.aat2738