Sci Adv: Weakly toxic malaria vaccine has initial lyins

May 21, 2020 /PRNewswire/--- In an innovative study, Radboudumc and LUM C jointly tested a weakly toxic malaria candidate vaccineThe results of the clinical trial, published in the journal Science Translational Medicine, show that the vaccine is safe and can trigger a defensive response to malaria infectionsmalaria is an infectious disease caused by malaria parasitesThe first stage of infection in humans occurs in the liver and the second stage in the bloodSince the liver stage does not cause any symptoms of the disease, but the blood stage causes the disease, the purpose of the vaccine is to block parasites in the liver(photo source:for the malaria vaccine in this study, researchers made the malaria parasite less pathogenic by removing two genes and developed a vaccine with American company Sanaria IncThe parasite can enter the liver, but because of its toxicity due to genetic manipulation, it does not cause blood infectionsIn the early stages of the study, the authors identified important genes that, in the absence of a parasite, prevent parasites from producing in the livertestresults showed that the vaccine was safeIt does not cause blood infection and therefore does not cause malaria symptomsIt was also observed that, although this protective effect was incomplete, vaccinated volunteers had an immune-defensive effect on malaria infectionThe researchers say the measured immune response and proven safety are a powerful impetus for further development of a genetically deficient malaria parasite vaccinemalaria is one of the leading infectious diseases of our time, with about 216 million cases and 400,000 deaths each yearThe number of infections has increased in recent years, particularly in sub-Saharan Africa and South Americamalaria is caused by the mosquito-borne malaria parasiteOnce in the body, the parasite first develops in the liver for about 7 days The parasite enters the bloodstream from the liver, infecting red blood cells The parasite then develops from asexual cells into mature male and female reproductive cells, which can then be absorbed by mosquitoes and then fertilized in the mosquito's stomach After a mosquito bite, the offspring can repeatedly infect humans (Bio Valley Bioon.com) Source: Scientists investigate epigenemechanisms of the cell cell
episcoande original origin: A double-blind, placebo-controlled phase 1/2a trial of the genetically available attenuated malaria vaccine vaccine SPZ-GA1.
Science Translational Medicine (2020) stm.sciencemag.org/lookup/doi/ .. scitranslmed.aaz5629