SCI adv: research reveals the relationship between intestinal microflora and allergy in infants

June 5, 2019 / BIOON / - a research team from several institutions in South Korea and Australia found that there may be a relationship between the intestinal microflora of infants and the occurrence of allergies In a paper published in the journal Science advanced, the team described their study of a specific antibody response in young mice and their findings In the past few years, food allergy has been widely reported, especially in children Scientists are studying the reason why the number of people who are allergic to certain foods seems to increase suddenly In the new study, the researchers looked at the link between food allergies and gut biomes Photo source: prior to the start of the science advanced study, some team members noticed that laboratory mice growing up in sterile environments (and without intestinal microbiota) expressed higher levels of immunoglobulin E (IGE) when they were mature enough to start eating solid food Previous studies have shown that IgE is a mediator and plays a role in anaphylaxis When allergens are detected, IGES signals other parts of the immune system, which in turn releases chemicals that cause inflammation, a major allergic symptom To find out why infertile mice produce more antibodies, the researchers divided one group into two groups, one fed a normal diet and the other fed a special diet that does not stimulate the immune system They reported that mice on normal food had a normal immune response, while mice on special food did not The team tried to delay the introduction of normal food to mice that ate special foods, because it was suspected that a lack of healthy gut microbiome might be related to immune responses triggered by certain foods There may be a link between the intestinal microbiota of infants and the development of allergies they report that this leads to a decrease in the level of increased IgE production Further observation showed that T-follicular helper cells participated in the enhanced immune response Such cells are usually more common in young mice (and children) That's why children are more likely to develop allergies than adults, the researchers said The researchers also found that if the diet restricted mice were mixed with the normal diet mice, the diet restricted mice would not produce a large number of t-follicle assistants, and the number of IgE would also decrease Reference: sun wood Hong et al Food antigens drive intermittent IgE elevation in the essence of commercial microbiology, science advances (2019) Doi: 10.1126/sciadv.aaw1507