Sci Adv . . . Liu Bin/Liu Xiaogang/Kong De-ling co-developed a new nanoimmune stimulator to remove malignant solid tumors.

After nearly ten years of development, immunotherapy has become one of the most promising methods to cure cancer.however, in the process of immunotherapy, how to avoid excessive activation of immune response and enhance the anti-tumor effect is still an urgent problem in the field.reactive oxygen species (ROS) are small molecules with oxidative capacity, which play an important role in cellular function and immune regulation.as a strong oxidant, excessive ROS is often used to kill tumors and induce immunogenic cell death (ICD), which can provide potential antigen stimulation for the immune system.on the other hand, low-dose ROS can act as a key signal molecule to promote the maturation of antigen-presenting cells and cytoplasmic antigen delivery through signal transduction, thus leading to effective antigen cross presentation and strong CD8 + T cell response.recently, Liu Bin and Liu Xiaogang of National University of Singapore and Kong Deling of Chinese Academy of Medical Sciences jointly published the title of aiegen coupled upconversion nanoparticles edicate solid tubes through dual mode ROS In this study, a novel near-infrared driven nano immunostimulator was developed, which was driven by up conversion of nanoparticles and aggregation induced emission, The combination of AIE photosensitizer integrates the immunological function of ROS in the anti-tumor process, enhances the adaptive immune anti-tumor response, thus effectively eliminates solid tumors and inhibits tumor metastasis, which provides a new research idea for tumor immunotherapy.the researchers first synthesized a novel AIE photosensitizer and upconversion particles chimeric nanomaterials.through precise chemical design, the absorption wavelength of AIE photosensitizer matches the emission wavelength of up conversion material accurately, realizing the generation of ROS with near-infrared fluorescence excited by high-efficiency near-infrared laser.during the treatment of malignant melanoma, high-dose ROS is produced by intratumoral injection of AIE upconversion nanoparticles under high-power NIR irradiation, which induces immunogenic cell death and antigen release.at the same time, these nanoparticles can capture and deliver tumor specific antigen released to lymph nodes and then be absorbed by dendritic cells (DCS).after the subsequent low-power NIR radiation for lymph nodes, the nano materials will produce low-dose ROS, further activate DC, and trigger effective CD8 + T cell immune response by inducing cross presentation of cell antigen, which can effectively prevent local tumor recurrence and distant metastasis tumor growth.to sum up, a dual-mode light driven AIE upconversion nanoparticle is used in this work, which integrates multiple biological functions of ROS for the first time, effectively eliminates malignant solid tumors and inhibits tumor metastasis.this technology provides a new powerful platform and treatment strategy for tumor immunotherapy.the first authors of this paper are Dr. Mao duo and Dr. Hu Fang, postdoctoral researchers of National University of Singapore.Professor Liu Bin and Liu Xiaogang from National University of Singapore and Professor Kong Deling from Peking Union Medical College of Chinese Academy of medical sciences are co authors of this paper.original link plate maker: Qi sauce