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December 5, 2020 // -- A recent study has linked disorders in the human gut microbiome to severe depression (MDD).
team described their study of stool samples from MDD patients and control groups in a paper published in the journal Science Advance.
MDD is an emotional disorder characterized by a persistent sense of sadness or a lack of interest in the stimulation of ordinary life.
believed to have biological origins and are therefore not just a reaction to events.
the new study, researchers suggest they have found evidence linking problems in the gut microbiome to MDD symptoms.
(Photo: www.pixabay.com) involved collecting 311 stool samples from 156 people with MDD and 155 without the disease.
genetic analysis was performed on each sample to identify microorganisms and other substances found in the sample.
team also conducted large-scale gas chromatography-mass spectromety analysis of samples to learn more about their composition.
researchers found differences in certain ingredients in samples without MDD.
, they found 47 different bacteria, as well as 50 fecal metabolites and three different phages.
as part of their findings, they also found higher levels of membership in the genus Bacillus bacterium species in MDD patients, and higher levels of bacteria in the real and cyanobacteria species.
think MDD may have microbiome problems.
team also noted that higher levels of mycobacteria in the microbiome may help explain why cytokines and associated inflammation levels rise in so many MDD patients compared to the general population.
researchers point out that the traditional way to diagnose MDD in patients is through the interview process - their findings suggest that it is also possible to test the presence of certain elements in the gut microbiome as part of any screening effort to confirm the disease.
() Source: Gut microbiomeances linked to major depressive disorder Source: Jian Yang et al. Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders, Science Advances (2020). DOI: 10.1126/sciadv.aba8555。
