SCI ADV: A new method for the steady state of mitochondrial mitochondrial targeting neurons
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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Mitochondrial dynamics and impaired function are hallmarks of many neurological and mental illnesses, but so far no precedent has been reported for the use of neurons to directly screen mitochondrial therapeutic drugsrecently, researchers developed a high-content screening experiment using primary neurons and identified 67 neuronal mitochondrial stable small molecular regulators (MnMs)most filtered MnMs increase the content, length, and/or health of the mitochondria, and also enhance mitochondrial function without altering the growth of neuronsin which a subset of MnMs protects mitochondria in primary neurons against the toxicity of A beta (1-42), glutamate and increased oxidative stresssome MnMs have been shown to be directed at mitochondriaThe most effective MnM also increased synaptic activity in hippocampus neurons and proved effective in the body, increasing the breathing rate of the brain mitochondria after injecting the compound into micetherefore, the results provide a platform for direct measurement of mitochondrial steady state in neuronsThese small molecular regulators, which affect mitochondrial dynamics and function, are also candidates for mitochondrial therapy
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