 Home > Biochemistry News > Biotechnology News > Scholars from the Chinese Academy of Sciences found that the regulation of serine metabolism plays an important role in the metastasis of colorectal cancer

Scholars from the Chinese Academy of Sciences found that the regulation of serine metabolism plays an important role in the metastasis of colorectal cancer

 Last Update: 2021-11-14
 Source: Internet
 Author: User

Tags

cell articles

cloaking technology

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

<>.

CRC is one of the most common malignant tumors of the digestive tract

Abnormal cell metabolism is closely related to the occurrence and development of tumors, and uncontrolled metabolism has become an important feature of cancer

Yang Weiwei's group research found that the monoubiquitination modification of PHGDH, a key enzyme in the serine synthesis pathway, promotes the transfer of CRC

By analyzing a large number of samples of CRC patients, they found that compared with CRC in situ tumor tissue, the content of SAM in liver metastasis tumor tissue was higher; compared with CRC patients without metastasis and recurrence, CRC patients with metastasis and recurrence contained serum The content of SAM is higher

This work discovered a new function of serine metabolism regulation to promote CRC metastasis; revealed a new mechanism for monoubiquitination to regulate PHGDH activity and SAM production to promote CRC metastasis; it suggested that blocking the serine synthesis pathway can inhibit liver metastasis of CRC and tumor tissues And the content of SAM in serum can predict the metastasis and prognosis of CRC

Researcher Yang Weiwei from the Center of Excellence for Molecular Cells, Professor David Li, Professor Li Xinxiang from Fudan University Cancer Hospital, and Professor Wang Xiongjun from Guangzhou University are the co-corresponding authors of the paper

Article link: https://

The monoubiquitination modification of PHGDH promotes liver metastasis of colorectal cancer

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

L-Ascorbate-2-Monophosphate Feed Grade

CAS No.: 109620-90-8

Feed Grade

Potassium Sorbate from reliable manufacturer

CAS No.: 590-00-1

Food Grade

Doxycycline Hydrochloride

CAS No.: 10592-13-9

Pharmaceutical Grade

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.