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This finding suggests that some of the most targeted mutations in medicine are not as common as previously thought
Cancer researchers have been using DNA sequencing technology for the past 15 years to identify genetic mutations that cause different forms of cancer
Picture: Salk's research combined cancer DNA mutation data and cancer development rate, and found the most common mutant genes in all cancers
This study, published in the journal Nature Communications on October 13, 2021, revealed the frequency of mutations in each gene in the genome in a population of cancer patients
This paper answers a very basic question: What are the most common mutated genes in human cancers? Stites said, "Surprisingly, this question has not been answered
Gene mutations play a fundamental role in the development and growth of cancer
In this new study, Stites' team combined genomic and epidemiological cancer research data sets to determine the proportion of any gene mutation in all cancer patients
To overcome this challenge, the scientists carefully analyzed more than 200 studies and reviewed and reclassified each cancer separately according to a consistent naming system
Stites said: “These findings indicate that it is necessary to reassess where people’s time, attention and resources are concentrated
Original title:
10.
Cancer gene mutation frequencies for the US population
