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Russia has developed an anti-hantavirus drug that is 5 times more effective than existing drugs

 Last Update: 2021-06-22
 Source: Internet
 Author: User

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Chemists from the People’s Friendship University of Russia, together with colleagues from Novosibirsk State University and the Novosibirsk Institute of Organic Chemistry, based on the VECTOR Center for Scientific Virology, obtained a new class of compounds that can inhibit the division of the deadly Hantavirus (the The virus affects human blood vessels and internal organs)
.

Compared with existing antiviral drugs, the compound's effectiveness is increased by 5 times

Hantavirus causes hemorrhagic fever with renal syndrome (HFRS)
.

The disease is common in Russia, China, South Korea, Finland, Sweden, and the Asian regions of Eastern and Central European countries

Fedor Zubkov (Associate Doctor of Chemistry, Associate Professor of the Department of Organic Chemistry, People's Friendship University of Russia) said: "There is great hope for the research on antiviral drugs based on terpenes, which are hydrocarbons that are abundant in many plants and their essential oils
.

We have previously discovered a new class of terpenoids that can effectively inhibit influenza virus, namely camphor-based hydrazone

In previous studies, acylhydrazones synthesized from camphor and anisone can inhibit smallpox and influenza viruses
.

One of these substances is the starting point of this work

The biological activity of the obtained compound was tested on a pseudovirus (a kind of biosafety virus) composed of the same glycoprotein as Hantavirus
.

Compared with real virus experiments, this "model" can evaluate biological activity faster and safer

Alexander Antonov (a student of the Department of Organic Chemistry at the People’s Friendship University of Russia) said: “This type of compound does not prevent the virus from entering the cell, but prevents it from replicating in the cell
.

Therefore, we can conclude that the obtained terpene The therapeutic target of the ene complex is the hantavirus protein responsible for the replication of the virus in the cell

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