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Rogue immune cells that steal proteins may worsen multiple sclerosis

 Last Update: 2022-04-21
 Source: Internet
 Author: User

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Multiple sclerosis (MS), an autoimmune disease in which immune cells strip the protective myelin insulation from nerves, has plagued researchers

One of the key mysteries is why some of the body's immune cells become dysfunctional

He added that this is the first time that some T cells have been found to steal a protein called CD20 from the surface of B cells

Although these cells occur in healthy people, they are more abundant in MS patients, and laboratory studies suggest they can be particularly damaging

They found that mouse T cells carrying CD20 did not produce the protein on their own

First, they grew the animals' B cells and CD20-free T cells in lab dishes

So Webb and his team investigated whether T cells take up CD20 from B cells in living mice

They also wrapped their cell membranes with more mucins, proteins that help them slip into nerves, where they can cause damage

But this may indicate that T cells have been activated by B cells, ready to start attacking myelin

Multiple sclerosis patients often receive treatments that target immune cells that carry CD20, which scientists have traditionally thought of as B cells

But if researchers can confirm this mechanism, it will be possible to design new, more specific treatments that can eliminate aggressive T cells without the often severe side effects of B cell loss

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