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Today, Arbutus Biopharma and Vaccitech jointly announced that the two companies have reached a clinical trial cooperation agreement that will evaluate an immunotherapy combination consisting of RNAi therapy and immunotherapy for the treatment of standard nucleoside (acid) reversals.
Hepatitis B is a potentially life-threatening liver infection caused by HBV
AB-729 is a subcutaneous RNAi therapy that uses Arbutus' new covalently coupled N-acetylgalactosamine (GalNAc) delivery technology to target liver cells
VTP-300 is an immunotherapy with the mechanism of action very similar to that of vaccines
Note: The original text has been deleted
Reference materials:
[1] Arbutus Biopharma and Vaccitech Announce Clinical Trial Collaboration Agreement to Evaluate RNAi Therapeutic, AB-729, in Combination with Immunotherapeutic, VTP-300, in Subjects with Chronic Hepatitis B Virus Infection.