Review: Stem cell technology to reverse premature ovarian failure

Everyone has a beautiful heart, and many women dream of being young forev.

But in fact, with the passage of time, when you see bags under your eyes and gray hair in the mirror, will you panic and sigh that beautiful women get old easily?

In fact, while the appearance is getting older, the function of the ovary, the most important reproductive organ of women, is slowly declini.

How to spot clues for ovarian decline?

Changes in weight and posture

Among the many signs of aging in women, weight change is often very common and sensitive, which is what we often call "fa.

The aging of the ovary is significantly earlier than that of the whole bo.

The body's basal metabolism is different, and the posture will also be very differe.

A Japanese study shows that aging in women begins in the abdom.

Once you enter the ovarian aging stage, you will find that the graceful curve of youth has disappeared quietly, abdominal fat begins to accumulate, waist circumference increases, lower limbs become thinner, elegant neck begins to shorten, and it is mostly manifested as weight ga.

Shortening of the menstrual cycle

As the saying goes, menstruation is the "barometer" of women's health, "if you see a woman's disease, ask the scriptures firs.

A shortened menstrual cycle is one of the easiest signs of ovarian decli.

Because with age, the number of remaining follicles in the ovary decreases, and the number of available follicles decreases accordingly, so the level of inhibin B secreted by the granulosa cells in the early follicle decreases, the level of FSH increases, and the early increase in FSH accelerates follicle development, resulting in an advantage Early recruitment of follicles, shortening of the follicular phase, and clinical manifestations of shortened menstrual cycl.

Shortening of the menstrual cycle,.

If your menstrual cycle used to be 35-40 days, and then gradually shortened to 25-30 days, you should be wary of ovarian agi.

Once a woman approaches menopause, ovulation becomes very irregular, menstrual cycles become more irregular, and menopause occurs when the follicles are deplet.

Always unable to get pregnant

When a woman is still a fetus, the ovary contains about 6 million to 7 million oocytes at 20 weeks of the embr.

Baby girls are born with only 1 to 2 million oocytes left, and by puberty, only 300,000 to 500,000 oocytes are le.

During the reproductive years, a woman releases about 400 to 500 mature eggs during her lifeti.

As women age, women's oocyte reserve decreases and ovarian function gradually declin.

The age of 35 was an important turning poi.

One study found that women who were infertile at age 35 experienced a decline in fertility by age 3 Then you experience infertility, shortened menstrual cycles, irregular periods, e.

, and eventually menopau.

The ovary is a warm home for human beings to nurture new li.

However, some women are still in their reproductive years with premature ovarian failure leading to infertility and the risk of losing fertili.

Overview of diseases of premature ovarian failure

Premature ovarian failure (POF) refers to ovarian failure due to various reasons in women before the age of 40, and is considered an "incurable disease" that leads to infertili.

Diagnostic criteria: amenorrhea for at least 4 months before the age of 40, FSH>40U/L for 2 or more times (the interval between two examinations is more than 1 month), and estradiol <72pmol.

The disease occurs in more than 1% of women of childbearing a.

In recent years, it has shown an upward and younger tre.

The two major threats to women's reproductive health from premature ovarian failure are reduced estrogen levels and loss of fertili.

Decreased estrogen levels increase a woman's risk of osteoporosis and coronary heart disea.

Women of childbearing age have early amenorrhea, decreased fertility, and are prone to psychological problems such as depression and anxie.

With the progress of stem cell research, it provides a new way for humans to understand the occurrence and development of diseases and develop new treatment metho.

Stem cell therapy has made great progress in the field of basic research, and some research results have been applied to various clinical trials such as tumor diseases, autoimmune system diseases, nervous system diseases, and cardiovascular diseas.

A large number of clinical data and related reports on the clinical research and application of stem cells have been publish.

A variety of stem cells are used to treat premature ovarian failure (POF)

Stem cells have the ability to repair and regenerate themselv.

Recent studies on animal models of premature ovarian failure have shown that stem cell therapy can improve ovarian structure and functi.

Therefore, stem cell transplantation may be an effective method for the treatment of premature ovarian failu.

Human Amniotic Stem Cells (hAMSC)

Human amniotic stem cells (hAMSCs) are stem cells isolated from the amniotic membra.

Human amniotic stem cells (hAMSCs) possess multiple differentiation abilities and anti-inflammatory effects similar to other pluripotent mesenchymal stem cells (MSC.

[3] Studies have found that transplantation of human amniotic stem cells (human amniotic stem cells, hAMSC) in experimental mice can reduce inflammatory cytokines, increase estrogen, and reduce FSH levels, thereby maintaining continuous and healthy growth of follicles, reducing follicle atresia rate, recovery fertili.

Umbilical cord mesenchymal stem cells (UCMSC)

Umbilical cord mesenchymal stem cells (UCMSCs) are pluripotent, non-hematopoietic progenitor cells that can differentiate into a variety of cell lineag.

[4] Animal experiments have shown that umbilical cord mesenchymal stem cell (UCMSC) transplantation can restore ovarian function and reproductive potential in POI mice, significantly reduce FSH levels, and increase serum AMH leve.

The mechanism of action of umbilical cord mesenchymal stem cells may be to increase ovarian angiogenesis, promote the proliferation of granulosa cells and the growth and development of follicl.

Placenta-derived stem cells (hPMSCs)

Human placenta-derived mesenchymal stem cells (hPMSCs) are also pluripotent, non-hematopoietic progenitor cells with highly differentiated and proliferative potenti.

Compared with other types of stem cells, human placenta-derived mesenchymal stem cells (hPMSCs) are easy to obta.

In animal experiments [5], mice injected with placenta-derived stem cells (hPMSC) intravenously recovered ovarian endocrine function mainly through two ways: increasing mouse transforming growth factor beta (inhibiting inflammation, promoting ovarian function recovery), reduce the interfering hormone gamma (inhibit ovulation, promote follicular atresi.

Bone marrow mesenchymal stem cells

Bone marrow mesenchymal stem cells (BMSCs) are low-immunogenic adult stem cells that, like other stem cells, have proliferative and pluripotent differentiation potential and can differentiate into bone, cartilage and fat under appropriate conditions cel.

It has the effect of enhancing endogenous cell function and regulating immune response, and can be used to repair tissue dama.

Furthermore, bone marrow mesenchymal stem cells (BMSCs) are easily isolated and grown in vit.

Several clinical trials [6] have shown that patients with POI have increased baseline estrogen levels, improved menopausal symptoms, and even successful conception through autologous bone marrow-derived mesenchymal stem cell transplantati.

Mesenchymal stem cells have broad prospects for the treatment of premature ovarian failure

Premature ovarian failure (POF) seriously affects the physical and mental health of young wom.

At present, hormone therapy is mainly used to relieve the symptoms of estrogen deficiency, but the effect is not go.

Stem cells have the potential of self-improvement and regeneration, which can improve ovarian function, increase the number of follicles, increase sex hormone levels, reduce granulosa cell apoptosis, and can be used to treat premature ovarian failure (POF) and infertili.

Mesenchymal stem cell transplantation has broad application prospects in the treatment of premature ovarian failu.

It is believed that with the progress of research, mesenchymal stem cells will bring good news to more patients with premature ovarian failure!

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