Review: A selection of Lancet research highlights on November 16, 2019

Breast CancerLocal or Post-Hemp Recurrence Risk StudyDOI: https://doi.org/10.1016/S0140-6736(19) 32313-Xresearchers recently examined the effects of the use of vertebral blockan analgesics and propofol local anaesthetic and the use of volatile anesthetic sypt adesic and opioid-type anestheticsunder 85 years of age, patients who were prepared to undergo primary breast cancer treatment participated in the study and were randomly treated with local anaesthetic-analgesics (vertebral blockand and propofol) or whole hexatoe (heptafluoroetheration) and opioid analgesicsThe main endpoint of the study was localized or metastatic breast cancer recurrence, and the secondary endpoint was 6 to 12 months of incision pain1043 patients received local anaesthetic-analgesics, 1065 patients received full hemp and followed up for 36 monthsLocal anaesthetic-analgesic group 102 patients relapsed (10%), while 111 patients in the whole hemp group relapsed (10%, HR-0.97)52% of patients in the local anaesthetic-analgesic group had incision pain at 6 months, 52% of the whole hemp group and 28% of the patients in the local anaesthetic-analgesic group had incision pain at 12 months, and 27% of the whole hemp group (OR-1.0)The incidence of neurotic chest pain was not significant between the groups for 6 or 12 months2)hypertensionthe battle for a single-drug first-line treatmentDOI: https://doi.org/10.1016/S0140-6736 (19) 32317-7the besthypertension treatment is still uncertain Current guidelines suggest that first-line drugs may be optional or pyrolymic reurea, angiogenic tensionin conversion enzyme inhibitors, angiogenesis tensionin receptor blockers, dihydroquine calcium channel blockers and non-dihydroquine calcium channel blockers, but lack of further validation of randomized trials recently researchers conducted a comprehensive framework study based on real-world research, using observationdata from millions of patients to assess the relative effectiveness and safety of drugs The main endpoints of the study were the relative risk of three primary diseases (acute myocardial infarction , hospitalization for heart failure and stroke), six secondary effectiveness and 46 safety outcomes The study collected data on 4.9 million patients, with no significant difference in effectiveness of each type of drug, but the efficacy of steroids or pyridine diuretics was better than angiotensin-converting enzyme inhibitors: the initial treatment of patients with acute myocardial infarction (HR,0.84), cardiac failure hospitalization (0.83) and stroke (0.83) had a lower risk and safety In contrast, non-dihydroquine channel blockers are slightly less effective than other types of drugs Comprehensive analysis of mental illness-related health indicators in DOI: https://doi.org/10.1016/S0140-6736 (19) 32316-5 Researchers recently analyzed health indicators for mental illness-related deaths the team analyzed data on 736,9926 people and found that the mortality rate for people with mental disorders was 28.70 per 1,000 people per year, significantly higher than the general population in Denmark (12.95) In addition, all types of mental illness were associated with higher mortality rates, which increased from 1.92 to 3.91 for substance use disorders All types of mental disorders are also associated with shorter life expectancy, with the annual loss of life increasing from 5.42 years for female glial diseases to 14.84 years for men with substance use disorders When specific causes of death were studied, men with any type of mental disorder had fewer years of life-loss due to cancer-related deaths than the general population, even though their cancer deaths were higher MedSci Source: MedSci Original