Reversing the human body's surface genetic biological clock may be achievable

small clinical study in California, USA, showed for the first time that it is possible to reverse the body's pre-mesogene biological clock. The observational genetic biological clock can be used to measure a person's physiological age.
over a one-year period, nine healthy volunteers took three common drugs, growth hormone and two diabetes drugs. By analyzing markers in the human genome, the researchers found that the average physiological age of the subjects decreased by 2.5 years. At the same time, the subjects' immune systems showed signs of re-activity.
results even surprised trial organizers. But the researchers note that the findings are preliminary because the trial is small and does not include a control group.
analysis of the study by Steve Horvath, a geneticist at the University of California, Los Angeles. "I thought the biological clock would slow down, but it's not going to reverse ... but it's not going to happen," he said. It's a bit of a futuro. The
was published September 5 in the journal Aging Cells.
May have some effect, but the results are not absolutely reliable because the study is small and not well controlled, " said Wolfgang Wagner, a cell biologist at the University of Aachen in Germany. "
the clock relies on the human body's exogenic genome, which includes chemical modifications that label DNA, such as methyl. The patterns of these labels change over a person's lifetime and reflect a person's biological age, which may be behind or beyond a person's actual age.
scientists used to construct an oscic genetic biological clock by selecting DNA methylation points in the genome. Over the past few years, Horvath has developed the most accurate biological clock as a pioneer in the study of the object clocks of the observational genetic students.
this latest trial is designed to test whether growth hormone can be safely used for the recovery of human thymus tissue. The thymus is located in the thoracic cavity between the lungs and the thoracic bone and is essential for effective immune function.
white blood cells are produced in the bone marrow and then mature in the thymus, where they become special T-cells that help the body fight infectious diseases and cancer. But after puberty, the thymus begins to contract and is gradually blocked by fat.
evidence from animal and some human studies that growth hormone stimulates thymus regeneration. But the hormone can also cause diabetes, so the trial included taking two anti-diabetic drugs widely used in cocktail therapy, dehydroformosterone (DHEA) and metformin.
test, called thymus regeneration, immunotherapy and insulin remission (TRIIM), tested nine white men between the ages of 51 and 65. The project was led by Gregory Fahy, chief scientific officer and co-founder of Los Angeles Intervention Immunization, and approved by the U.S. Food and Drug Administration in May 2015. A few months later, it began at Stanford Medical Center in Palo Alto, California.
in the TRIIM trial, scientists took blood samples from subjects during treatment. Tests showed that each person's blood cell count became more active. The researchers also used magnetic resonance imaging to determine the thymus composition of the subjects at the beginning and end of the study. They found that in seven subjects, the accumulated fat was replaced by recycled thymus tissue.
the effects of these drugs on the subjects' esogenetic biological clocks were only later thought of. By the time Fahy found Horvath wanted to do an analysis, the clinical study was complete.
Horvath assessed each person's physiological age using four different psycheological biological clocks, and the results showed a significant reversal in the condition of each participant in the test.
Horvath, said: "It tells me that the biological effects of this treatment are powerful. More importantly, he said, the effect persisted in the six participants who provided the final blood test six months after the trial was discontinued.
we can track changes in everyone's body, and everyone's reaction is very strong, so I'm optimistic," Horvath said. Now
, researchers are already testing the potential of metformin to prevent common age-related diseases, such as cancer and heart disease. Fahy says three drugs in cocktail therapy may have a unique mechanism for biological aging.
Intervention immunity company is planning a larger study that will include women of all ages and ethnicity, as well as women.
fahy says thymus regeneration may be more useful for people with an inactive immune system, including the elderly. Pneumonia and other infectious diseases are the main causes of death among people over the age of 70.
, a cancer immunologist at Heriot-Watt University in Edinburgh, UK, said it was exciting to see immune cells dilate in the blood. This "has a huge impact not only on infectious diseases, but generally on cancer and overall ageing". (Source: China Science Journal Zhao Xixi)
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