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Reveal key functions of important genes in leukemia

 Last Update: 2022-10-03
 Source: Internet
 Author: User

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The oncogene EVI1 causes an aggressive leukemia, but its exact function has been a mystery

In cancer cells, chromosomes are often destroyed and recombined, which leads to changes

Johannes Zuber of the Institute of Molecular Pathology (IMP) said: "We have many experimental tools to study gene function in cancer, but in EVI1-driven cases of AML, we lack the relevant disease models

Eventually, overcoming many difficulties, Inês Barbosa, then a doctoral student in Zuber's lab, succeeded in creating a new model of EVI1-driven AML that made genetic experimentation possible

Johannes Schmoellerl, who was a doctoral student in Grebien's lab before joining Zuber lab as a postdoc, uses "gene scissors" CRISPR-Cas9 to eliminate genes

The scientists then tried to find out exactly how important

Johannes Schmoellerl said: "While there are different mechanisms that can lead to the expression of EVI1, their main function is focused on

EVI1 drives leukemogenesis through aberrant ERG activation

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