Resting fMRI detects full-brain function connection impairment in glioma patients

Glioma is a disease that affects the whole brain, and the spread of tumor cells extends far beyond the visible lesionsAt present, neuroradiology imaging can only show the subject of the tumor and its adjacent lesionsVeit M Stoecklein, of Neurosurgery at Ludwig-Maximilians University in Germany, used mrI imaging based on resting state function to assess the functional continuity of the entire brain in glioma patients and to speculate that brain functional connections in patients with aggressive high-level tumors were more damaging than in patients with low-level tumorsThe results were published online in February 2020 by Neuro-Oncologymethods of study
there may be two mechanisms for glioma cells to alter the functional connections of the brain: first, glioma cells migrate beyond the tumor itself, resulting in damage to functional connections, so that the invasion of glioma cells to the brain impairs the integrity of neurons; Second, in glioma patients, with the increase of oxygenated blood flow, the brain vascular system's ability to respond to neuronal activation is seriously impaired, and the invasive glioma cells can replace healthy astrocytes, resulting in the loss of vascular contraction or diastolic abilityAs a result, damage to functional connections may be detected by detecting blood oxygen concentration dependence (Blood Oxygen Level-Dependent, BOLD)The author obtains the Anomaly Index (ABI) by detecting the abnormality of the BOLD quantization function connection by the rest-setting function MRI imaging toolAnd in a group of newly diagnosed glioma patients34 glioma patients were included in the study, including 13 WHO II, 6 WHO CLASS III and 15 WHO IV tumorsAnalysis of the RESULTS of BOLD testing found that abnormal brain coherence occurs not only in the damaged brain region of the hemisphere where the glioma is located, but also in the opposite hemisphereIndividual detection of patients has the following manifestations: in 1 case of glioblastoma (Figure 1A) patients and 1 case of left pillow locell tumor (Figure 1B) patients found abnormal index of functional connection; For glioblastoma; the damage to brain tissue function in patients with low-level glioma (Figure 1D) is not obvious; the damage to the functional continuity of the brain of large, low-grade gliomas (Figure 1 E, 1F) is limited to the tumor side hemisphere, and is closely related to the tumor aggression shown in the WHO classificationAt the same time, the results showed that IDH1 mutant tumors were associated with abnormal connections to brain function, and that THE ABIs in idh 1 wild tumor patients were significantly higher than those with IDH1 mutant tumorsNot only that, the abnormal index is negatively correlated with neurocognitive function, indicating the direct impact of tumor subjects on cognitive performanceFigure 1Detection of BOLD shows typical manifestations of impaired brain function connections in glioma patientsthe results of the study
the authors used resting function MRI to detect the brain hemisphere BOLD to analyze the functional connection, found that glioma patients neural function connection abnormalities not only exist in the lesions and adjacent areas, but also can appear in the lesions in the distant brain tissue even on the opposite hemisphere Abnormal neural function connections are associated with tumor biology and cognitive impairment in patients Based on traditional MRI enhancement techniques, the diagnostic method provides a more comprehensive assessment of glioma patients, and can individualize the scope and severity of glioma, with potential clinical value in developing effective treatment programs.