Researchers predict for the first time when bacteria will become resistant to antibiotics

In a new study led by researchers from University College London and Great Ormond Street Hospital, scientists have found signs of "pre-resistance" in bacteria for the first time-specific bacteria that may develop resistance to antibiotics in the future Signs

The results of this study are published in the journal Nature Communications, which will enable doctors to choose the best treatment for bacterial infections in the future

A team led by the Great Ormond Street Hospital (GOSH) and the University College London’s Great Ormond Street Children’s Health Institute collaborated with the Peruvian Tuberculosis Project and was funded by Wellcome and the National Institutes of Health (USA).

Mycobacterium tuberculosis (TB) is a bacterial infection that mainly affects the lungs

Multidrug-resistant tuberculosis is a huge and unsustainable burden, and completely drug-resistant strains have been found in a few countries

In order to better understand and ultimately better treat tuberculosis, this new study determines for the first time how to preemptively preempt drug-resistant mutations

By analyzing thousands of bacterial genomes, this research may be applied to other infectious diseases and pave the way for personalized pathogen "genome therapy"

This work is the result of 17 years of research in the outskirts of Lima, Peru, where Dr.

This international research team compared tuberculosis samples from 3135 different samples and reconstructed the "family tree" of tuberculosis bacteria-commonly known as phylogeny

The authors describe how mutations in the tuberculosis genome predict that a particular branch may develop drug resistance, and then validated their findings in an independent global tuberculosis data set

Dr.

"This is the first example to show that we can overcome resistance

Arturo Torres Ortiz, the first author of the paper and a doctoral student at the University College London’s Great Ormond Street Institute for Children’s Health, said: “We hope this discovery can provide a way to treat difficult conditions that are most likely to develop resistance in the future.

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