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Image: This image shows the optical clearing process of brain tissue to visualize the three-dimensional blood vessel network in fluorescence imaging
Source: Osaka University
When it comes to cancer, understanding the situation is the key
They published their findings in the online edition of Macromolecular Biosciences on June 21, and published the print edition on September 16
Since 1981, cancer has been the leading cause of death in Japan," said the first author, Chie Kojima, associate professor at the Faculty of Engineering, Osaka Prefecture University
This type of imaging involves labeling specific molecular machines, such as proteins, so they will fluoresce in different colors depending on what they are
Previously, researchers used a method called CLARITY to embed tissues in polyacrylamide hydrogels
For practical applications, the optical cleaning time of the CLARITY method needs to be shortened," Kojima said
To shorten the time, the researchers used zwitterionic hydrogels, which maintain a balance among charged molecules and maintain the structure of the tissue sample
Using our system, the blood vessel network and metastatic tumor tissue in mouse brain tissue can be displayed in 3D
They can see the tumor tissue faster than before: it used to take a month, but the improved method can be realized in a week
Researchers are continuing to explore this technology and how it can be used to diagnose human cancer
We are trying to apply our system to pathological diagnosis," Kojima said
DOI
10.
Application of Zwitterionic Polymer Hydrogels to Optical Tissue Clearing for 3D Fluorescence Imaging
