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"Ribosomes are the building blocks of life, but we don't yet have a complete understanding of how they fit together and how the ribosome production process is regulated," said lead author Michael Buszczak, Ph.
Dr.
While every species has ribosomes, most of what is known about ribosome biogenesis comes from a popular laboratory model, yeast
To learn more about this process, Dr.
Using a gene-editing tool called CRISPR, the researchers inactivated individual genes to identify those that may play a key role in ribosome biogenesis
The function of SPATA5 in cells was not previously known; however, mutations in the gene have been linked to neurodevelopmental disorders, including microcephaly, hearing loss, epilepsy and intellectual disability
Dr.
This work was supported by grants from the National Institute of General Medical Sciences (GM125812 and GM144043), and grants from the Simons Cancer Center
Other UTSW researchers involved in the study include Daniel A.
Dr.
Journal Reference :
Chunyang Ni, Daniel A.
