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Image: The microfiber device developed by the School of Engineering at Virginia Tech can make cancer immunotherapy more effective
Cancer immunotherapy is one of the most important and promising therapies in cancer treatment.
"However, there is still an obstacle to achieving modest success," said Rong Tong, an assistant professor in the Department of Chemical Engineering.
Professor Tong came to Virginia Tech in 2015.
Tong and Jia decided to combine their efforts to help fight cancer.
Their initial team included their first batch of graduate students, chemical engineering PhD students Chin Ailin (expected to graduate this fall) and Jiang Shan (obtained a PhD in electrical engineering in May 2021 and are currently a postdoctoral researcher at Stanford University)
By using the optical fiber embedded in the electrode, it has the ability of local delivery and measurement that lasts for several weeks, combined with local immune checkpoints to block antibody delivery and photodynamic therapy, researchers have been able to induce continuous anti-tumor immunity in a variety of tumor models.
"We can inject antibodies into the tumor through our microfibers, activate the T cells around the tumor cells, and further trigger anti-tumor immunity by recruiting more T cells to the tumor bed," Jia said
Tong said that the team's treatment method, from local to whole body, is very different from the traditional treatment method that only uses the whole body
Tong said that the study found that the use of this new device to measure tumor electrical signals (tumor impedance) is fast and can monitor tumor growth in real time, which is very different from traditional contrast agent-based tumor imaging therapies
"When the tumor grows, the impedance reading increases accordingly; when the tumor becomes smaller due to antibody treatment, we also find that the tumor becomes smaller
"Nature Communications" is an open-access multidisciplinary journal dedicated to publishing high-quality research in the fields of biology, health, physics, chemistry, and earth sciences
“When Jia and I started this study, they were both young and enthusiastic teachers at Virginia Tech.
