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    Home > Biochemistry News > Biotechnology News > Researchers develop porous nanoparticles for regenerative medicine

    Researchers develop porous nanoparticles for regenerative medicine

    • Last Update: 2022-04-22
    • Source: Internet
    • Author: User
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    Akhilesh K.


    Two-dimensional COFs (porous organic polymers) have attracted much attention due to their crystallinity, order-tunable porous structure, and high specific surface area


    Gaharwar's team enhanced the hydrolytic (water) stability of COFs by combining them with amphiphilic polymers


    "To our knowledge, this is the first report that COFs can direct stem cells to bone tissue," Gaharwar said


    The researchers found that even at higher concentrations, 2D COFs did not affect cell viability and proliferation


    These nanoparticles are highly porous, and Gaharwar's team took advantage of this unique property for drug delivery


    "These nanoparticles can prolong the time of drug delivery to human mesenchymal stem cells, which are normally used for bone regeneration," said the study's senior author Sukanya bunia, a postdoc in the Department of Biomedical Engineering


    After providing a proof of concept, Gaharwar noted, the next step for the team will be to evaluate the nanotechnology in diseased models


    These findings have important implications for the future design of biomaterials, which could provide directions for tissue regeneration and drug delivery applications


    The findings were published in the journal Advanced Healthcare Materials


    Journal Reference :

    1. Sukanya Bhunia, Manish K.



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