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Akhilesh K.
Two-dimensional COFs (porous organic polymers) have attracted much attention due to their crystallinity, order-tunable porous structure, and high specific surface area
Gaharwar's team enhanced the hydrolytic (water) stability of COFs by combining them with amphiphilic polymers
"To our knowledge, this is the first report that COFs can direct stem cells to bone tissue," Gaharwar said
The researchers found that even at higher concentrations, 2D COFs did not affect cell viability and proliferation
These nanoparticles are highly porous, and Gaharwar's team took advantage of this unique property for drug delivery
"These nanoparticles can prolong the time of drug delivery to human mesenchymal stem cells, which are normally used for bone regeneration," said the study's senior author Sukanya bunia, a postdoc in the Department of Biomedical Engineering
After providing a proof of concept, Gaharwar noted, the next step for the team will be to evaluate the nanotechnology in diseased models
These findings have important implications for the future design of biomaterials, which could provide directions for tissue regeneration and drug delivery applications
The findings were published in the journal Advanced Healthcare Materials
Journal Reference :
Sukanya Bhunia, Manish K.