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Recently, Li Fei's research team from the Frontier Science Center of Disease Molecular Networks of our hospital published online research results "Polyamine metabolism links gut microbiota and testicular dysfunction" in the journal Microbiome (IF=14.
65)
.
The project's research found that drug-induced testicular damage can disrupt the dynamic balance of intestinal flora and reduce testicular polyamine levels.
Dr.
Qi Zhao from our institute and Dr.
Jianfeng Huang from Kunming Institute of Botany, Chinese Academy of Sciences are the co-first authors of this article.
Researcher Li Fei from our institute and Professor Weifeng Zhu from Jiangxi University of Traditional Chinese Medicine are co-corresponding authors
.
West China Hospital of Sichuan University is the first signing unit
Data show that infertility affects 12% of the world's right-age couples, of which male reproductive dysfunction accounts for about 50%
.
Genetic defects, chemical exposures such as endocrine disruptors and chemotherapy all affect male reproductive function
The intestinal flora is the second largest genome in the human body and participates in various physiological functions of the liver, intestines, brain and other organs.
However, the mechanism of intestinal flora and testicular damage is not clear
.
Recent studies have reported that the abnormal function of the mouse testis caused by the plasticizer di-(2-ethylhexyl) phthalate (DEHP) may be closely related to the disorder of the intestinal flora
The study used triptolide-induced mouse testicular damage as a model, using metabonomics and metagenomics analysis to find that triptolide inhibits the biosynthesis and absorption of polyamines, and at the same time disrupts the dynamic balance of polyamine-producing bacteria
.
Spermine supplementation can improve testicular damage in mice by increasing sperm production, and at the same time increase the number of offspring mice
Original link: https://microbiomejournal.
