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Lymph node metastasis is a sign of the deterioration of cancer patients, and timely treatment is essential
A research team at tohoku University's Graduate School of Biomedical Engineering in Japan has developed a lymphatic drug delivery system (LDDS) in which anti-cancer drugs are injected directly into metastatic lymph nodes
TBI provides a uniform dose of radiation throughout the body, penetrating areas
The team hopes to expand the use of LDDS to prevent distant metastasis — the spread of cancer from the primary tumor to distant lymph
Sora and his colleagues studied the dual treatment
In vivo bioluminescent imaging systems, high-frequency ultrasound systems, and histograms show that the new therapies are more effective
Sora added: "Since the results show that both TBI and LDDS improve the efficacy of LB metastases and distant metastases, this new approach is a promising way
Combination therapy of lymphatic drug delivery and total-body irradiation in metastatic lymph node and lung mouse model