Research results of Professor He Yun's team of Chongqing University published in nature

On September 4, 2018, Professor He Yun's team from Chongqing University (CQU) School of pharmacy, in cooperation with the Affiliated Children's Hospital of Chongqing Medical University and the Gates Foundation global health drug research and development center of Tsinghua University, published a study entitled "total synthesis and Professor He Yun is the only corresponding author, Lin Zihua, Xu Xiaobo and Zhao Sheng, doctoral students of Professor He Yun's research group, and Chongqing University are the first authors All the experimental work was completed by the team of Chongqing University The widespread use of antibiotics, especially the problem of bacterial resistance caused by antibiotic abuse, has become one of the most difficult problems in clinical treatment The emergence and spread of multidrug-resistant bacteria and even "superbacteria" have posed a new threat to human health Therefore, it is urgent to develop new antibiotics Albomicins (grisein) is a kind of natural products with significant antibacterial activity, which was isolated from the metabolites of Streptomyces griseus in 1947 Its structure is composed of siderophore and thionucleoside compounds (such as sb-217452), which are very important for the growth of bacteria This paper reported the first total synthesis of ALBOMYCIN δ 1, δ 2 and ε, and tested the activity of these three natural products, among which ALBOMYCIN δ 2 showed excellent antibacterial activity, and its minimum inhibitory concentration was generally lower than that of antibiotics in use on the market Ciprofloxacin, vancomycin and penicillin also had a good inhibitory activity on MRSA, the minimum inhibitory activity was 0.25 μ g / ml, and the antibacterial activity against Streptococcus pneumoniae reached the level of nanogram / ml Moreover, early studies have shown that ALBOMYCIN has a good safety, so this kind of compounds have a good potential to further develop into effective anti bacterial drug resistance drugs The school of pharmacy takes the lead in building a drug platform focusing on drug resistance of bacteria, developing albomicin series compounds and other new antibiotics to meet the challenge of drug resistance of bacteria.