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On August 28, Advanced Science, an international authoritative journal, published an online article entitled "Synthetic "retinoid kills drug-resistant cancer stem cells via inducing RARγ translocation mediated tension reduction and chromatin decondensation", jointly revealing that the original targeted anticancer drug-a novel retinoic acid analog WYC-209 efficiently induces the apoptosis of malignant tumor stem cells and inhibits cancer New Mechanobiological Mechanisms of Metastasis
Cancer stem cells have the characteristics of high self-renewal ability and high tumorigenicity, and are an important culprit of tumor metastasis and recurrence
To this end, Professor Chen Junwei's team further explored and found that WYC-209 induces chromatin loosening in the nucleus by reducing the cell traction of cancer stem cells, thereby activating apoptotic genes, and efficiently inducing cancer stem cell apoptosis
Biomechanical medicine (Mechanomedicine) is a rapidly developing and exciting new field proposed by Professor Wang Ning of the University of Illinois based on the concept of biomechanics
Professor Chen Junwei from the School of Life Sciences has been committed to force regulation of gene expression and its application in the field of biomechanical medicine, and has collaborated with Professor Wang Ning of the University of Illinois to publish a number of important original achievements in this field: in 2014, he found that Sox2 gene is a tumor in a low stress environment The key factor of regenerative cell metastasis and recurrence (Nature Communications, 2014), based on this achievement, we cooperated with the team of Academician Yu Biao of Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences to explore and discover a new targeted anticancer drug WYC that specifically kills malignant tumor regenerative cells -209 (Nature Communications, 2018); and subsequently found that the direct activation of gene expression by mechanical signals into the nucleus depends on the demethylation of histone H3K9 (Science Advances, 2020), and found that mediating force transmission into the nucleus to activate gene transcription.
Original link: http://doi.
