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Research develops a new 'magic bullet' therapy that promises to treat patients with acute myeloid leukemia

 Last Update: 2022-02-26
 Source: Internet
 Author: User

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Recent studies have found that sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) may act as a key tumor checkpoint, thereby enhancing the expression and function of programmed death ligands

Expression of high sialic acid-binding immunoglobulin-like lectin (Siglec)-15 on the surface of circulating blood cells in patients with acute myeloid leukemia (AML)

Image credit: DOI: 10.

This innovative "magic bullet" technology utilizes specific antibody targeting technology, thereby reducing the need for current therapies that are difficult, invasive and require long-term hospitalization of patients

The researchers found high concentrations of a molecule called Siglec-15 on the surface of diseased cells in AML patients, and they also identified a molecule that binds Siglec-15, which can enter cells and carry away a molecule.

In AML patients, Siglec-15 is expressed at higher levels than in healthy cells, so the researchers set out to exploit this overexpression for follow-up studies.

The researchers said that AML is a major killer of human death, especially for the elderly.

Note: The original text has been deleted

Original source:

Huan Cao, Andreas Neerincx, Bernard de Bono, et al.

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