Regulatory mechanism of gut microbiome in the formation of anti-vibriomycosis traits in semi-slippery tongue rays

On September 23, 2022, Microbiome, the world's top microbiome journal, published online the title "Intestinal microbiome-mediated resistance against vibriosis for" by the team of Professor Ning Kang of the School of Life Sciences and Technology of Huazhong University of Science and Technology (Huashi University) and the team of academician Chen Songlin of the Yellow Sea Fisheries Research Institute (Yellow Sea Institute) of the Chinese Academy of Fishery Sciences Cynoglossus semilaevis" research paper
.

During the two sessions of the National People's Congress in 2022, General Secretary Xi Jinping made a comprehensive and systematic exposition on the establishment of the "big food concept", pointing out that "it is necessary to ask for food from rivers, lakes and seas and stabilize aquaculture"
.

Semi-slippery tongue fish (scientific name: Cynoglossus semilaevis), also known as mammoth, dragon li, scorpion, rice and tongue fish, is an important marine aquaculture fish in China, is one of the nine major varieties of the national marine fish industry technology system, its taste is delicious, nutritious and high
economic value.

Based on the multigenerational selection of the semi-slippery tongue fish disease resistance family by Academician Chen Songlin's team, this study analyzed the structural and functional differences, host gene expression patterns and flora-host interaction of the intestinal flora of the disease-resistant and susceptible families through multi-omics analysis, and found that the microbial community structure of the disease-resistant and susceptible families was significantly different: the disease-resistant families enhanced the anti-Vibrio infection ability by recruiting beneficial bacteria (such as Phaeobacter, Propionibacterium).

Figure 1.
Regulatory patterns of intestinal microbiota in the formation of anti-vibrinosis traits in semi-slippery tongue rays

Figure 2.
Assessment of the ability of the intestinal microbiome and host gene to jointly screen semi-slippery tongue rays against Vibrio Harvey's disease

This study reveals for the first time the molecular mechanism of intestinal microorganisms regulating the anti-vibriobacterial traits of semi-slippery tongue fish by regulating host immune homeostasis and reducing inflammation response, and the "bacteria-intestine-immune axis" regulatory model revealed will help to understand the role of intestinal flora in the formation of fish disease resistance traits, provide a new perspective for the study of fish disease resistance traits, and lay an important foundation
for opening up new ways for fish disease control and fine breeding.

The above work was completed with the support of the National Natural Science Foundation of China, the National Key Research and Development Program, and the Shandong Taishan Scholars Climbing Program
.

References:

Qian Zhou1, Xue Zhu1, Yangzhen Li, Pengshuo Yang, Shengpeng Wang, Lei Wang, Kang Ning*, Songlin Chen*.

Paper Link: https://microbiomejournal.