Recent scientific achievements in the field of stomach cancer research!

In !-- article, we've compiled and shared recent scientific achievements in the field of stomach cancer research! Photo credit: pursuit.unimelb.edu.au1: Chinese scientists have developed a new technology that promises to quickly lock stomach cancer cells doi:10.1126/sciadv.aba9 Stomach cancer is the world's third leading cause of cancer death, with more than 1 million new cases each year and about 800,000 deaths each year, mainly due to poor prognosis for stomach cancer patients due to the difficulty of researchers in early diagnosis of peritina metastasis of stomach cancer.
the separation and identification of tumor cells is very important for the early diagnosis of cancer peritoneal metastasis, however, due to the low content of cancer cells in peritoneal scrubs in cancer patients, traditional detection methods often lack sensitivity to meet clinical needs.
, in a recent study published in the international journal Science Advances, scientists from the Shenyang Institute of Automation of the Chinese Academy of Sciences and others developed an optically induced electrodynamics microflow method that can be used for unlabeled separation and characterting of stomach cancer cells.
First, researchers created an OEK-based microflow chip to isolate stomach cancer cells from the patient's abdominal water and analyze their electrochemical characteristics, and then they created a cell polymerization model and a cell membrane capacitive solution model.
: Revealing that EBV promotes a new mechanism for gastric cancer by reprogramming the host's osesopic genetic landscape doi:10.1038/s41588-020-0665-7 gastric cancer is the third leading cause of cancer death among the world.
one of the most common human viruses, Epstein-Barr virus, also known as EBV, is associated with about 8 to 10 percent of stomach cancers.
In a new study, researchers from Chiba University in Japan, the Singapore Science and Technology Research Agency and Duke-Singapore National University revealed a new pattern of EBV-related stomach cancer, in which the EBV virus genome directly alters the host's metastatic genetic landscape, promoting the activation and tumor development of proto-oncogene, a gene involved in normal cell growth that can become carcinogenic when mutated.
study was published online online in the journal Nature Genetics.
the human genome is a complete collection of human genetic information, and the esoteric genome describes modifications to the genome that determine whether genes are turned on or off when and where they are needed.
unlike genetic information, the esoteric genome is dynamic and the response to external stimuli, which can cause abnormal modification of DNA, which in turn disrupts normal gene expression and leads to cancer.
, the researchers conducted a comprehensive analysis of the three-dimensional genome structure of human cells.
this involves stomach cancer cell line, patient samples, normal gastric cortectal cells, and EBV-related stomach cancer.
combined with virus infection analysis, they found abnormally activated genomic regions specific to EBV-positive stomach cancer.
in in-body cultured stomach cells infected with EBV, they recreated how EBV binds to these inactivated closed genomic regions and causes them to become abnormally active.
( 3) BJBMS: Identification of the independent biomarker doi:10.17305/bjbms.2020.4620 Although scientists have made many advances in the diagnosis and therapeutic research of stomach cancer in recent years, it is still an important public health problem, so in addition to classical methods, scientists need new biometric molecules to help predict the prognosis of gastric cancer and develop targeted therapies.
, scientists from Turkey's Feirat University identified a new independent prognosm index for stomach cancer in a study published in the international journal Bosnian Journal of Basic Medical Sciences.
researchers say P2X7 is a special molecule that is thought to play a number of important roles in inflammatory events and cancer progress, and that the subject is located on the cell membrane and increases its level in many types of cancer.
Previously, researchers found that P2X7 subjects may be biomarkers of adverse prognostics of a variety of malignant tumors, such as pancreatic, colorectal and kidney cancers, but after recent studies of cancer cell line, scientists have found that P2X7-like antagonists are effective in slowing tumor growth, but no detailed clinical studies have been conducted to investigate the effects of P2X7 on the prognostic effects of P2X7 on the treatment of stomach cancer patients.
Mol Case Studies: Bio-informational tools to help find the stomach cancer drug doi:10.1101/mcs.a004945 In a recent study, researchers at the Moscow Institute of Physical Technology and colleagues developed the first personalized gastric cancer treatment based on tumor cell RNA sequencing.
the study was published in the journal Cold Spring Harbor Molecular Case Studies with the support of the Russian Science Foundation.
cancer is the fifth largest cancer in the world.
are rarely diagnosed at an early stage, which complicates treatment.
there are several treatment options available, often relying on chemotherapy and therapeutic antibodies.
, however, the patient's response is often unpredictable and requires personalized therapies and drug prescriptions tailored to the situation.
therapeutic antibodies can be used to treat relapsed tumors in the stomach.
block the recipients on the surface of the cell responsible for receiving growth-promoting signals.
which in turn causes cell division to stop and reduce the size of the tumor.
, preventing the growth of tumor blood vessels is particularly important because they provide nutrients and oxygen to the tumor.
is a therapeutic antibody used to disrupt the growth of blood vessels in tumor tissue.
the efficacy of the drug varies from patient to patient.
: Uncovering the Key Role Of Stem Cells in Fatal Gastric Cancer !--/ewebeditor:page--!--ewebeditor:page title"--doi:10.1 038/s41467-019-13847-2 In a recent study published in the international journal Nature Communications, scientists from Cornell University made new discoveries in the study of common and fatal stomach cancer.
In the United States, the incidence of gastroesophageal cancer has increased 2.5-fold from the 1970s to the early 2000s, but the number of all stomach cancer patients has fallen by more than 80 per cent since the 1950s; in the
study, researchers identified a new path of gastroesophageal cancer that could potentially be a potential target to help develop new therapies; a class of stem cell offspring called Lgr5 plus may come together in large numbers to promote cancer when two stomach tissues meet.
researcher Professor Alexander Nikitin said: 'At the global level, gastric squamous column junction cancer (gastric esophageal cancer) is a frequent disease in patients with poor prognostic conditions, so it is important to study the mechanisms of the formation of such cancers and how to treat them.'
Photo Source: commons.wikipedia.org: Limiting specific bacterial infections helps prevent stomach cancer doi:10.1053/j.gastro.2019.10.019 Recently, researchers at the Perelman School of Medicine at the University of Pennsylvania found that successful removal of helicobacter pyridobacteria from the gastrointestinal tract reduced the risk of gastrointestinal cancer by 75 percent.
also found that the incidence of stomach cancer was higher when Helicobacterrobacteria infections were detected in specific populations, suggesting that specific populations could benefit from more careful monitoring.
the study was published in the journal Gastroenterology.
estimates that half of the world's population is infected with Helicobacterrobacteria, with the main patients located in the eastern part of the world.
infection can cause ulcers and other gastrointestinal problems, but in most people it does not cause health problems, so many people do not know they have been infected.
researchers say African-Americans, Asians, Hispanics and Latinos, Amerindians and Inuit have a significantly higher risk of Helicobacterrobacteria and stomach cancer.
men, smokers and older people with Helicobacterrobacteria are also at higher risk than the general population.
J Gastroenterol: New Discovery! Special cell masks may hide stomach cancer doi:10.1007/s00535-019-01596-4 There is a cell at the point of gastric cancer lesions that looks like a normal gastric mucous membrane In a recent study published in the international journal Journal of Gastroenterology, scientists from Hiroshima University revealed the origin of this layer of cells, which are produced by cancer tissue itself.
Helicobacter pylori is a class of bacteria that live in the human stomach and must mesolyse stomach acid in order to survive in harsh stomach environments, while the bacteria are also a leading cause of stomach cancer; In the
study, researchers found that after treating Helicobacter pyridosis infections, there was a very strange cell layer at the patient's stomach cancer lesions, called ELA (low-level heterogeneous epithelial cells), similar to normal mucous membrane cells in the stomach and like a mask capable of hiding stomach cancer, which until now has not been known to researchers.
researcher Dr Chayama said: 'We are very interested in studying why stomach cancer still relapses after the bacteria are removed, and antibiotics are often used to treat Helicobacter pyridosis infections, but bacterial infections often leave scars on the stomach.'
: Oncogene: 40 years apart! Scientists shed light on the new molecular mechanism of Helicobacter pyridobacteria that causes stomach cancer doi:10.1038/s41388-019-0702-01982, when researchers discovered a link between chronic gastritis and Helicobacter pyridosis. Helicobacterrobacterium is a large number of studies, the results show that, in addition to causing gastritis, Helicobacterium is also a key factor in inducing stomach ulcers and stomach cancer, the current researchers clearly illustrate the link between this bacteria and a variety of stomach diseases, but how Helicobacterium in the end induced stomach tumors, the scientific community there is still a lot of controversy.
Forty years later, scientists from Japan's Kinema University and others have revealed the molecular mechanisms of helicobacter pyridosis-induced inflammation that promotes the proliferation of upper-cored stem cells in the stomach, which in turn triggers stomach tumors, according to research published in the international journal Oncogene.
, the researchers describe how they have made ground-breaking new findings based on previous research. 'Previously, we've found that tumor necrotic factor alpha (TNF-alpha), which promotes inflammation in the body, may promote the production of stomach tumors by activating the function of the NOXO1 protein, but we don't know how NOXO1 induces stomach tumors,' said
researcher Dr. Canae Echizen.
NOXO1 is a component of the NOX1 complex, which produces tissue-damaged molecules - reactive oxygen (ROS), and the oxidative stress reaction triggered by ROS triggers mutations in DNA in stomach cells, triggering tumor formation and inflammation caused by Helicobacter pyridosis infections, which increases oxidative stress in the stomach.
PNAS: Special drugs may be able to effectively inhibit the occurrence of stomach cancer by inducing helicobacter pyridoigen mutations: 10.1073/pnas.1814497116 In a recent study published in the international journal Proceedings of the National Academy of Sciences, a study from Vander Scientists at the University of Fort Medical Center have found that many types of drugs currently being treated as a chemotherapy agent may also show great potential in treating stomach cancer; in addition to being known to block the growth of cancer cells, drugs called DFMO (DFMO) can directly reduce the toxicity of Helicobacter pylori, the main cause of stomach cancer.
!--/ewebeditor:page--!--ewebeditor:page"--gastric cancer is the third most common cause of death in cancer patients, and the results of this paper support further research into how DFMO prevents stomach cancer; Stomach tissue, but only about 1% of those infected develop stomach cancer, and although we can prevent it by treating it, researchers don't know who to treat it, and Helicobacter pyrethroids have some beneficial effects - esophageal reflow disease, asthma and other allergic diseases are more common in people who are not infected with Helicobacter pyrethroids.
: Scientists hope to develop a new gastric cancer treatment, doi:10.1158/0008.