Recent important results to interpret new advances in cancer stem cell research!

in !-- webeditor:page title" -- In this article, we compiled several recent important research results to share with you the new advances that scientists have made in the field of cancer stem cell research! Photo credit: IRB Barcelona 1 Cell Stem Cell Deep Interpretation! How to release the anti-cancer potential of immunotherapy by targeting cancer stem cells! doi:10.1016/j.stem.2020.07.017 Scientists from the National Institutes of Health and others have revealed how By targeting cancer stem cells to unlock the potential of immunotherapy, the researchers identified residual cancer stem cells (CSCs) as mechanisms for cancer tolerance to immunotherapy by studying head and neck squamous cell carcinoma (HNSCC), targeting CCS or promising to increase the efficiency of immunotherapy to reduce tumor recurrence and metastasis.
With more than 600,000 new head and neck squamous cell carcinoma (HNSCC) patients worldwide each year, the incidence rate is the sixth highest in the world, with a five-year survival rate of only 63% for HNSCC patients because of the limited response of patients to currently available therapies and the frequent recurrence of disease; SCC treatment is revolutionary, but unfortunately, less than 20 percent of patients respond to ICB, which works primarily by blocking PD-1, but often does not produce lasting responses, and researchers urgently need to develop new ways to achieve lasting cures and disease recurrence.
: Cell Stem Cell: Blocking the biosynthetic of proteins or promising to curb the function of cancer stem cells Doi:10.1016/j.stem.2020.04.012 Not all cells are identical in tumors, colon cancer contains differentiated cells (which resemble functional cells in the intestinal wall) In a recent study published in the international journal Cell Stem Cell, scientists from institutions such as the Barcelona Institute of Biomedical Research found that the polypotential nature of colon cancer stem cells is its ability to synthesize proteins, a trait that researchers may use as a target to develop new cancer treatments.
researcher Battle says the current treatment for colon cancer is not very effective because it doesn't remove all erythrocytes, and several studies have found that when cancer stem cells are removed experimentally, other differentiated cells return to a multi-potential state and regenerate tumors, a phenomenon researchers call malleable.
: Plant-derived SVC112 molecule attacks cancer stem cells, inhibits head and neck cancer growth doi:10.1158/0008-5472.CAN-19-3232 Red tube flowers from Bouvardia Ternifolia in Mexico and the southwestern United States attract hummingbirds.
firecrackers also provide a chemical bouvardin.
Dr. Tin Tin Su and others at the University of Colorado Cancer Center in the United States have found that wave-outings can slow the production of proteins that allow cancer cells to grow and spread.
Now, in a new study, Su's team has found that wave-based SVC112 molecules synthesized by SuviCa, a Colorado-based pharmaceutical company, specifically attack head and neck cancer stem cells, resulting in better tumor control and less toxicity to healthy cells than existing protein synthesis inhibitors approved by the U.S. Food and Drug Administration (FDA).
hope these promising preclinical results will lay the groundwork for SVC112 to conduct human clinical trials in patients with head and neck cancer, the results of which were recently published in the journal Lancer Research.
researchers say proteins called transcription factors are key to initiating genetic processes in cells.
tell these cells to grow, stay in place, and metaseed.
stem cells (CSCs) are a sub-group of cancer cells.
, CSCs often resist treatments such as radiotherapy and chemotherapy, and once the treatment is over, they can survive and re-open tumor growth.
: By targeting cancer stem cells or promising cures for acute myeloid leukemia doi:10.1038/s41586-019-1835-6, a study published in the international journal Na In the study, scientists from institutions such as the Peter McCallum Cancer Centre in Australia found a new method of targeting acute myeloid leukemia at its root, which could help develop new treatments for malignant, incurable blood cancer. In the
article, researchers identified a specific target in AML stem cells that could be used as a specific target for the development of new drugs, and AML stem cells are key to supporting leukemia progression, which, although rare, is the main cause of AML resistance to current anticancer therapies.
researcher Mark Dawson says current treatments for AML are good at eliminating major cancer cells, but they often leave very rare leukemia cells, triggering a recurrence of the cancer after treatment.
: New biomarkers for identifying cancer stem cells Promise to develop highly effective anti-cancer therapies doi:10.1038/s41598-019-51004-3 In the world of cancer biology, not all biomarkers are the same, and these molecules can alert doctors that abnormal processes in the patient's body may be under way, in the form of a series of abnormal proteins, such as hormones, enzymes, or signaling molecules, and that they vary from person to person.
Because it's a mixture, no drug is effective at targeting it; in a recent study published in the international journal Scientific Reports, scientists from the University of Houston and others found a new biomarker in cancer stem cells that could actually direct the survival and spread of cancer, and the results could potentially help researchers develop new drugs to target cancer stem cells, thereby curbing cancer progression.
!--/ewebeditor:page--!--ewebeditor:page-title"--researcher Gomika Udugamasooriya says we found this protein called mesh protein in cancer stem cells. Plectin's new biomarker, mesh protein, may be used as a new target to help researchers develop available cancer drugs; mesh protein is a special structural protein that is expressed primarily in cells, but is directly related to the invasive and metastasis of tumors on cell surfaces.
photo source: en.wikipedia.org: J Hepatol: Researchers have demonstrated the potential of treating liver cancer with targeted cancer stem cells doi:10.1016/j.jhep.2019.08.035 Liver cancer is the world's second leading cause of cancer-related death.
most common primary liver cancer in adults is called hepatocellular carcinoma (HCC), which kills about 780,000 people each year.
even with advanced surgical treatment or transplantation, the five-year survival rate of HCC patients is still very low, due to the frequent recurrence of hepatocellular carcinoma.
now, a new study by researchers at the National University of Singapore (NUS) has revealed a potential treatment for advanced liver cancer, such as HCC.
team of NUS scientists led by Associate Professor Edward Chow of the NUS Institute of Cancer Sciences (CSI) and Dr. Toh Tan Boon, Head of the Translational Core Laboratory at the NUS Institute of Health, has shown that a class of small molecule drugs targeting JAK/STST can be used to fight cancer.
in clinical trials of other diseases, molecular mechanisms that target chemotherapy resistance have shown success.
, this targeted treatment can be used as an auxiliary treatment to improve the clinical prognosis of HCC patients.
7 (Xinhua) -- Scientists at the University of Toledo have developed an improved approach to a common chemotherapy drug that could eradicate cancer stem cells by destroying cancer stem cells to effectively treat breast cancer doi:10.1038/s41598-019-42251-5 Toledo University.
their findings could be not only a breakthrough in the treatment of tumours, but also a breakthrough in ensuring that cancer does not return years later -- to reassure patients that their disease is indeed over.
"Not all cancer cells are the same, even in the same tumor," said Dr. William Taylor, a professor in the Department of Biological Sciences at the University of Toledo's School of Natural Sciences and Mathematics.
" there are a lot of mutations, some cells, like cancer stem cells, are even more annoying.
everyone is trying to kill them, and that's probably one way.
cancer stem cells are of interest to researchers because they have the potential to reseed tumors.
when a doctor surgically removes the tumor, or treats the tumor with chemotherapy or radiotherapy, the tumor may disappear.
, however, there is evidence that a small number of adaptable tumor cells can survive and circulate in the body, sowing new metastasis seeds in distant places.
PNAS: Revealing that the protein JAG1 plays a key role in cancer stem cell differentiation and metastasis Doi:10.1073/pnas.1815345116 In a new study, researchers from Rice University and Duke University in the United States found that a smaller protein --- JAG1--- appears to play a key role in how cancer stem cells differentiate and metastasize.
, they found that JAG1 interacted with notch signaling paths, which play a vital role in regulating the fate of cells.
cells form tissue arranged on the outer surface of the organ.
are migratory cells that are usually involved in processes such as wound repair.
epithelial-mesenchymal transition (EMT) is a process of converting epithelial cells into migrating interstitial cells.
cancer hijacks the process and becomes most invasive by stopping it from forming metastasis hybrid cells in the middle stage.
: Cancer Cells May Use Normal Genes in Special Ways to "Doi": 10.1158/0008-5472.CAN-1 8-0330CDK1 is a normal protein that drives cells through the replication cycle, while MHC Class 1 molecules are also normal molecules that present small amounts of protein on the cell surface for immune system examination; In a study published in the international journal Lancer Research, scientists from the University of Colorado Cancer Center found that cancer cells labeled MHC Class 1 and high levels of CDK1 showed unusually high levels of MHC Class 1 molecules. And CDK1 is often the key to certain diseases, such as melanoma, pancreatic cancer and colon cancer, and in fact these cells may be cancer stem cells that scientists have long sought, and once cancer patients are treated, they become resistant to chemotherapy. and reseed the seeds of cancer.
Usually, cancer researchers grow tumors and then look for drugs or genetic changes that promote tumor growth or atrophy, but in the current study, researchers don't want the size of the tumor to change, but rather what factors promote tumor growth in the first place.
to answer this question, the researchers used patient samples, mouse models, and public genetic data to study genetic commonality in cells that can cause melanoma, pancreatic and colon cancers.
JCI: Vitamin C can inhibit the production of tumor stem cells! doi:10.1172/JCI121685 Cancer, is an oddly changing word that can cause fear and anxiety.
as a result, many women with cancer and treatment experience chronic stress and depression.
scientists have found in experiments in humans and rodents that stress accelerates cancer progression, but it is not clear what mechanisms are behind it.
A recent study published in Journal of Clinical Investigation by Dalian Medical University, Sun Yat-sen University and others revealed the secret: the stress hormone epinephrine triggered a series of biochemical reactions that led to the growth and metastasis of cancer cells.
!--/ewebeditor--page--!--ewebeditor:page title"--In this study, researchers first demonstrated the effects of chronic stress on the growth of cancerous stem cells, something that had not been the focus of previous studies.
researchers used a mouse model of immunodeficiency and found that chronic stress-induced epinephrine promotes the production of cancer stem cell-like properties in breast cancer cells, mainly by resetting the metabolic pathways that rely on lactate dehydrogenase (ALDHA).
() more exciting inventory! Stay tuned! !-- / ewebeditor: page --