Rapid detection of abnormal genes Breast cancer metastasis analyzers approved in the United States

the U.SFood and Drug Administration (FDA) announced on the 16th, a gene search BLN test analyzer, used to check for breast cancer metastasis gene detection system approved in the United StatesDeveloped by Veridex, a company owned by Johnson and Johnson, the real-time reverse transcription polyenzyme chain reaction (RT-PCR) principle can quickly detect breast-specific genes (MG) and epithelial cell-specific genes (CK-19) with high levels in the outpost lymph nodes, helping surgeons determine breast cancer metastasis and determine whether breast cancer patients need to perform lowerly-arm lymph node cleaningIt is the first high-precision laboratory detection system at the molecular level in the field of breast cancer detectionThe first lymph node senode seisile that is required for themetastasis of breast cancertumoris is called the "outpost lymph node"Normally,healthypeople with no MG or a very small amount of CK-19 in their lymph nodesBut for breast cancer patients, when both genes or one of them exceeds a certain amount in the outpost lymph nodes, it is indicated that the cancer may have spread to the lymph nodes, especially the lower armpit snodesUnderarm lymph node cleaning reduces the likelihood of future recurrence and further spread of cancer, thus prolonging the life of the patientHowever, lymph node cleaning can have serious sequelae, such as limited physical activity, long-term edema and lymphatic inflammation, affecting the quality of life after surgeryA number of clinical studies over the past decade or so have shown that removing the lower lymph nodes does not prolong the patient's survival or reduce the recurrence rate when the cancer has not yet metastarateTherefore, in this case, a large area of cleaning the lymph nodes is not necessaryHowever, when the positive outpost lymph nodes were missed during the operation and subsequently discovered for more accurate pathology, the patient had to go back to thehospital perform lymph node cleaning This type of secondary surgery can place a lot of mental and financial burden on the patient It can be seen that the accuracy of the detection of cancer spread during surgery is the key to reducing unnecessary lymph node cleaning and avoiding secondary surgery The BLN detection system's rapid detection of cancer spread allows the master knife doctor to understand the metastasis of the patient's cancer cells in the lymph nodes and make the final decision during breast cancer surgery According to data released by the U.S FDA, the analyzer was 88 percent accurate in patients with breast cancer metastasis and 94 percent in breast cancer patients who did not have metastasis The results of a one-on-one comparison study with the usual interoperative cryobiopsy showed that the detection rate of BLN was 95.6%, while the freezing biopsy was 85.6% The study also showed that the false positive rates of BLN and cryobiopsy were 5.7% and 2.2%, respectively