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▎The content team editor of WuXi AppTec.
Regarding the health effects of Omega-3 fatty acids, in addition to the prevention and treatment of cardiovascular diseases, there has also been research evidence in recent years suggesting the potential effects on Alzheimer's disease (AD)
.
Recently, a study published in the Journal of Alzheimer's Disease further evaluated the effects of supplementation with Omega-3 fatty acids on biomarkers in the cerebrospinal fluid of patients with Alzheimer's disease
.
The results found that although the patient’s memory performance improved, the biomarkers did not change significantly, and the changes in individual indicators were not related to the memory performance score
.
Professor Yvonne Freund-Levi, a neuroscientist at Örebro University and the corresponding author of the study, pointed out: “This study is the first time these new biomarkers have been collected to determine the effects of taking Omega-3 fatty acids on the Alzheimer’s The role of silent disease
.
" Screenshot source: Journal of Alzheimer's Disease This research is based on the discovery of the research team 15 years ago
.
At that time, a study covering more than 200 Alzheimer's disease patients showed that the Omega-3 ingredients in supplements can enter the brains of patients
.
The study included 33 patients with mild to moderate Alzheimer's disease, of which 18 patients took Omega-3 fatty acid supplements 2.
3 g in the morning and evening, and 15 patients served as a control group
.
The researchers collected cerebrospinal fluid samples from all subjects, analyzed the effects of daily supplementation of Omega-3 fatty acids on more than 10 biomarkers in cerebrospinal fluid, and performed memory tests on patients at the beginning of the study and 6 months later to explore these Whether there is a correlation between the biomarkers and the patient’s memory performance
.
The Mini Mental State Examination Scale (MMSE) used in the study is the preferred scale for dementia screening, with a total score of 0-30 points
.
Scoring reference: 27-30 points: normal cognitive function; <27 points: cognitive dysfunction; 21-26 points: mild cognitive dysfunction; 10-20 points: moderate cognitive dysfunction; 0-9 points : Severe cognitive impairment
.
It was found that the memory function of the patients in the Omega-3 group was stable, while the patients in the control group deteriorated
.
But when the research team looked at the various biomarkers in the cerebrospinal fluid samples, they did not see any difference between the two groups
.
In the group supplemented with Omega-3 fatty acids, two markers related to damaged nerve cells increased, that is, YKL-40 and NfL both increased slightly, while other biomarkers in the cerebrospinal fluid remained stable
.
The increase of YKL-40 and NfL suggests that inflammation and axonal damage may increase
.
However, these two biomarkers have no clinical relationship with the patient's memory performance
.
Professor Yvonne Freund-Levi pointed out: These data are not enough to allow us to change the recommendations to patients, but the study also brings interesting evidence
.
It can be seen from the results of the study that patients who took Omega-3 fatty acid supplements in the early stages of the disease scored higher on the memory test
.
At present, we recommend that patients need to perform physical activity and increase the intake of Omega-3 fatty acids in their diet (in the form of eating oily fish or taking supplements)
.
"Professor Freund-Levi added: "This research has also taken an important step forward.
In the future, researchers will be able to examine the biomarkers in blood samples without having to perform spinal puncture operations on patients, which can allow patients Free from pain
.
"Related reading "The Lancet" sub-issue: Can fish oil prevent Alzheimer's disease? Clinical trials suggest key factors: JACC: Eat more Omega-3 fatty acids to improve the outcome of myocardial infarction, and the effects of different ingredients promote new understanding and reduce the risk of cardiovascular events How to eat fish oil? 40% of Chinese people are at risk of stroke.
Innovative fish oil ingredients bring new hope for prevention! Harvard scholars led the release of the research results.
Source: 123RF Reference Materials [1] Tofiq, A.
, Zetterberg, H.
, Blennow, K.
, Basun, H.
, Cederholm, T.
, Eriksdotter, M.
, .
.
.
& Freund-Levi, Y.
(2021).
Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial—The OmegAD Study.
Journal of Alzheimer's Disease, (Preprint), 1-11.
[2] Stable memory test scores for Alzheimer's patients with omega-3 intake.
Retrieved SEPTEMBER 7, 2021, FROM https://medicalxpress.
com/news/2021-09-stable-memory-scores-alzheimer-patients.
html Disclaimer: WuXi AppTec's content team focuses on introducing global biomedical health research progress
.
This article is for information exchange only For the purpose of this article, the opinions in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the opinions
in the
article .
This article is not a treatment plan recommendation
.
If you need guidance on the treatment plan, please go to a regular hospital for treatment
.
Regarding the health effects of Omega-3 fatty acids, in addition to the prevention and treatment of cardiovascular diseases, there has also been research evidence in recent years suggesting the potential effects on Alzheimer's disease (AD)
.
Recently, a study published in the Journal of Alzheimer's Disease further evaluated the effects of supplementation with Omega-3 fatty acids on biomarkers in the cerebrospinal fluid of patients with Alzheimer's disease
.
The results found that although the patient’s memory performance improved, the biomarkers did not change significantly, and the changes in individual indicators were not related to the memory performance score
.
Professor Yvonne Freund-Levi, a neuroscientist at Örebro University and the corresponding author of the study, pointed out: “This study is the first time these new biomarkers have been collected to determine the effects of taking Omega-3 fatty acids on the Alzheimer’s The role of silent disease
.
" Screenshot source: Journal of Alzheimer's Disease This research is based on the discovery of the research team 15 years ago
.
At that time, a study covering more than 200 Alzheimer's disease patients showed that the Omega-3 ingredients in supplements can enter the brains of patients
.
The study included 33 patients with mild to moderate Alzheimer's disease, of which 18 patients took Omega-3 fatty acid supplements 2.
3 g in the morning and evening, and 15 patients served as a control group
.
The researchers collected cerebrospinal fluid samples from all subjects, analyzed the effects of daily supplementation of Omega-3 fatty acids on more than 10 biomarkers in cerebrospinal fluid, and performed memory tests on patients at the beginning of the study and 6 months later to explore these Whether there is a correlation between the biomarkers and the patient’s memory performance
.
The Mini Mental State Examination Scale (MMSE) used in the study is the preferred scale for dementia screening, with a total score of 0-30 points
.
Scoring reference: 27-30 points: normal cognitive function; <27 points: cognitive dysfunction; 21-26 points: mild cognitive dysfunction; 10-20 points: moderate cognitive dysfunction; 0-9 points : Severe cognitive impairment
.
It was found that the memory function of the patients in the Omega-3 group was stable, while the patients in the control group deteriorated
.
But when the research team looked at the various biomarkers in the cerebrospinal fluid samples, they did not see any difference between the two groups
.
In the group supplemented with Omega-3 fatty acids, two markers related to damaged nerve cells increased, that is, YKL-40 and NfL both increased slightly, while other biomarkers in the cerebrospinal fluid remained stable
.
The increase of YKL-40 and NfL suggests that inflammation and axonal damage may increase
.
However, these two biomarkers have no clinical relationship with the patient's memory performance
.
Professor Yvonne Freund-Levi pointed out: These data are not enough to allow us to change the recommendations to patients, but the study also brings interesting evidence
.
It can be seen from the results of the study that patients who took Omega-3 fatty acid supplements in the early stages of the disease scored higher on the memory test
.
At present, we recommend that patients need to perform physical activity and increase the intake of Omega-3 fatty acids in their diet (in the form of eating oily fish or taking supplements)
.
"Professor Freund-Levi added: "This research has also taken an important step forward.
In the future, researchers will be able to examine the biomarkers in blood samples without having to perform spinal puncture operations on patients, which can allow patients Free from pain
.
"Related reading "The Lancet" sub-issue: Can fish oil prevent Alzheimer's disease? Clinical trials suggest key factors: JACC: Eat more Omega-3 fatty acids to improve the outcome of myocardial infarction, and the effects of different ingredients promote new understanding and reduce the risk of cardiovascular events How to eat fish oil? 40% of Chinese people are at risk of stroke.
Innovative fish oil ingredients bring new hope for prevention! Harvard scholars led the release of the research results.
Source: 123RF Reference Materials [1] Tofiq, A.
, Zetterberg, H.
, Blennow, K.
, Basun, H.
, Cederholm, T.
, Eriksdotter, M.
, .
.
.
& Freund-Levi, Y.
(2021).
Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial—The OmegAD Study.
Journal of Alzheimer's Disease, (Preprint), 1-11.
[2] Stable memory test scores for Alzheimer's patients with omega-3 intake.
Retrieved SEPTEMBER 7, 2021, FROM https://medicalxpress.
com/news/2021-09-stable-memory-scores-alzheimer-patients.
html Disclaimer: WuXi AppTec's content team focuses on introducing global biomedical health research progress
.
This article is for information exchange only For the purpose of this article, the opinions in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the opinions
in the
article .
This article is not a treatment plan recommendation
.
If you need guidance on the treatment plan, please go to a regular hospital for treatment
.
