Radiology: Using thorium MRI to assess the amount of glycozysolutions in tumors

Backgroundtumor cells often have a high rate of aerobic glycolysis, which can provide a sugar decomposition product for the organisms needed for the rapid growth and proliferation of cellsExisting clinical methods (fluoro-deoxyriboite PET, carbon 13 MRI and spectral) do not quantify the flux of glycolysispurpose
this study aims to obtain quantitative mapping of tumor glycolysis flux and evaluate chemotherapy responses using radon MR spectral imagingmaterials and methodsthe time resolution of the rapid 3D 2H MR spectrum imaging sequence was 10 minutes, and the glycolysis flux imaging was done after the injection of glucose D-6,6'2H2 glucose before the tumor mouse model was treated with chemical therapy and 48 hours after treatmentTumor lactate markers were compared with lactate-water-to-glucose signal sylactatand and evaluated by local 2H MR spectrumStatistical evaluation was made using the paired sample T testresults2H MR spectral imaging showed differences in glycozy flux in tumors, and decreased glycozy flux in tumors after chemical drug treatmentThe spectral measurements of 5 mouse tumor models showed a decrease in the lactate-water signal ratio, from 0.33 to 0.089 to 0.089 (P.005), and the lactate-glucose signal ratio also decreased, from 0.27 to 0.12 to 0.12 to 0.06 (P.04)conclusions
rapid collection of thorium MR spectral imaging can quantitatively evaluate glycolysis flux and show differences in spatial distribution within tumors, which can be used to evaluate therapeutic responses