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    Home > Active Ingredient News > Antitumor Therapy > Radiology: MRI radiogenomics for medulloblastoma in children

    Radiology: MRI radiogenomics for medulloblastoma in children

    • Last Update: 2022-09-07
    • Source: Internet
    • Author: User
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    With the development of imaging techniques, MRI prediction of medulloblastoma (MB) molecular subsets provides a noninvasive preoperative pathway


    Although most rare in MB, WNT mutations have the best prognosis and are therefore most likely to benefit


    Machine learning can mine high-dimensional image features, aiding in precise analysis of quantitative features


    Recently, a study published in the journal Radiology formed a large pediatric MB cohort in 12 major centers in the United States, Canada and the United Kingdom, and developed an IBSI-based radiogenomics strategy to achieve early and accurate identification and diagnosis of four clinically significant SUBgroups of MB molecules


    This retrospective study evaluated consecutive pediatric patients with new diagnoses of MB on MRI at 12 international paediatric sites


    The study cohort included 263 patients (mean age at diagnosis± SD, 87 months±60; 166 boys



    This study proposes an MRI-based machine learning decision-making pathway and predicts four clinically relevant subgroups


    Original source:

    Michael Zhang,Samuel W Wong,Jason N Wright,et al.


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