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Radiology: Application of these MRI markers in predicting early treatment response in patients with multiple myeloma

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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Multiple myeloma (MM) is a hematological malignancy characterized by the malignant proliferation of monoclonal plasma cells in the bone marrow

Diffusion-weighted imaging MRI is a means of monitoring response to treatment in myeloma, quantitatively using visual assessment of high b-value images and apparent diffusion coefficient (ADC) values before treatment and during or after induction therapy

Quantification of bone marrow fat fraction is another MRI-based marker for monitoring MM patients

Recently, in a study published in the journal Radiology, I explored the role of early changes in bone marrow relative fat fraction (rFF) and ADC histogram metrics in predicting overall best response status in newly diagnosed MM patients following a cycle of induction therapy.

This prospective study included MM patients enrolled between August 2014 and December 2017

A total of 23 participants (mean age, 65 ± 11 [SD]; 13 males) were evaluated

This study demonstrates that early changes in bone marrow signal fat fraction histogram indicators calculated from in-phase and in-phase gradient echo MRI scans obtained at baseline and after only one cycle of induction therapy can predict outcomes in newly diagnosed multiple myeloma participants.

Original source:

Vassilis Koutoulidis, Evangelos Terpos, Nikolaos Papanikolaou, et al.

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