Radiology: Application of STAIR-UTE MRI sequence in myelin imaging

 

 

Demyelination is a sign of many inflammatory and neurodegenerative diseases.
Demyelination of this type of disease usually shows high signal on T2-weighted MRI images
.

However, this MRI high signal manifestation can occur in demyelinating diseases and other brain abnormalities (such as edema or gliosis), and is not a specific manifestation of a certain disease

Demyelination is a sign of many inflammatory and neurodegenerative diseases.

The ultra-short echo time (UTE) sequence with an echo time of less than 50 microseconds can directly detect the signal of myelin protons in the brain

At this stage, in order to solve these problems, a new short repetition time (TR) STAIR-UTE technology has been introduced in the clinic, which can provide more effective long T2 signal suppression without changing the T1 signal in the white matter.

Recently, a study published in the journal Radiology explored the feasibility of using the STAIR-UTE sequence under 3T MRI to image ultrashort T2 myelin protons in the white matter of healthy volunteers and multiple sclerosis (MS) patients, and compared MS The myelin content measured by UTE in patients and health volunteers proves its clinical value, and provides a more accurate and direct imaging method for clinical evaluation of demyelinating lesions

Both simulation and model studies show that STAIR-UTE technology can effectively inhibit long T2 tissues with a large T1 range
.

This study evaluated 10 healthy volunteers (mean age, 33 years ± 8 [standard deviation]; six women) and 10 MS patients (mean age, 51 years ± 16; seven women)

Figure 1 This figure shows the correlation between the signal intensity of multiple sclerosis (MS) and NAWM in 10 MS patients measured by T2-FLAIR and STAIR UTE sequences and NWM signal intensity in 10 healthy volunteers
.

There was a moderate correlation between T2-FLAIR and UTE measurements in MS lesions (r = -0.

Figure 2 A representative three-dimensional STAIR UTE whole brain volumetric medulla imaging image, with a TR of 140 msec and a reversal time of 61 msec
.

This study shows that the combination of a three-dimensional STAIR UTE sequence and a single short TR-reversal time can effectively inhibit the long T2 component in the white matter of a large T1 range, and can perform selective volume imaging of the myelin in the white matter of the brain
.

The measurement of myelin content by STAIR-UTE is an effective imaging method for evaluating demyelination and remyelination

Original source:

Ya-Jun Ma , Hyungseok Jang , Zhao Wei , et al.
Myelin Imaging in Human Brain Using a Short Repetition Time Adiabatic Inversion Recovery Prepared Ultrashort Echo Time (STAIR-UTE) MRI Sequence in Multiple Sclerosis .
DOI: 10.
1148/radiol.
2020200425

Both simulation and model studies show that STAIR-UTE technology can effectively inhibit long T2 tissues with a large T1 range
.

The three-dimensional STAIR-UTE sequence effectively suppresses the signal of water in the white matter and can selectively image myelin.

Figure 1 This figure shows the correlation between the signal intensity of multiple sclerosis (MS) and NAWM in 10 MS patients measured by T2-FLAIR and STAIR UTE sequences and NWM signal intensity in 10 healthy volunteers
.

There was a moderate correlation between T2-FLAIR and UTE measurements in MS lesions (r = -0.

Figure 2 A representative three-dimensional STAIR UTE whole brain volumetric medulla imaging image, with a TR of 140 msec and a reversal time of 61 msec
.

This study shows that the combination of a three-dimensional STAIR UTE sequence and a single short TR-reversal time can effectively inhibit the long T2 component in the white matter of a large T1 range, and can perform selective volume imaging of the myelin in the white matter of the brain
.
The measurement of myelin content by STAIR-UTE is an effective imaging method for evaluating demyelination and remyelination
.

Original source:

Ya-Jun Ma , Hyungseok Jang , Zhao Wei , et al.
Myelin Imaging in Human Brain Using a Short Repetition Time Adiabatic Inversion Recovery Prepared Ultrashort Echo Time (STAIR-UTE) MRI Sequence in Multiple Sclerosis .
DOI: 10.
1148/radiol.
2020200425

Figure 1 This figure shows the correlation between the signal intensity of multiple sclerosis (MS) and NAWM in 10 MS patients measured by T2-FLAIR and STAIR UTE sequences and NWM signal intensity in 10 healthy volunteers
.
There was a moderate correlation between T2-FLAIR and UTE measurements in MS lesions (r = -0.
43; P = .
04)
.
NAWM and NWM have a low correlation between T2-FLAIR and UTE measurements
.
These differences were not statistically significant (NAWM: r = -0.
09, P = 0.
14; NWM: r = 0.
04, P = 0.
84)
.

Figure 1 This figure shows the correlation between the signal intensity of multiple sclerosis (MS) and NAWM in 10 MS patients measured by T2-FLAIR and STAIR UTE sequences and NWM signal intensity in 10 healthy volunteers
.
There was a moderate correlation between T2-FLAIR and UTE measurements in MS lesions (r = -0.
43; P = .
04)
.
NAWM and NWM have a low correlation between T2-FLAIR and UTE measurements
.
These differences were not statistically significant (NAWM: r = -0.
09, P = 0.
14; NWM: r = 0.
04, P = 0.
84)
.
There was a moderate correlation between T2-FLAIR and UTE measurements in MS lesions (r = -0.
43; P = .
04)
.
NAWM and NWM have a low correlation between T2-FLAIR and UTE measurements
.

Figure 2 A representative three-dimensional STAIR UTE whole brain volumetric medulla imaging image, with a TR of 140 msec and a reversal time of 61 msec
.

Figure 2 A representative three-dimensional STAIR UTE whole brain volumetric medulla imaging image, with a TR of 140 msec and a reversal time of 61 msec
.

This study shows that the combination of a three-dimensional STAIR UTE sequence and a single short TR-reversal time can effectively inhibit the long T2 component in the white matter of a large T1 range, and can perform selective volume imaging of the myelin in the white matter of the brain
.
The measurement of myelin content by STAIR-UTE is an effective imaging method for evaluating demyelination and remyelination
.

This study shows that the combination of a three-dimensional STAIR UTE sequence and a single short TR-reversal time can effectively inhibit the long T2 component in the white matter of a large T1 range, and can perform selective volume imaging of the myelin in the white matter of the brain
.
The measurement of myelin content by STAIR-UTE is an effective imaging method for evaluating demyelination and remyelination
.

Original source:

Original source:

Ya-Jun Ma , Hyungseok Jang , Zhao Wei , et al.
Myelin Imaging in Human Brain Using a Short Repetition Time Adiabatic Inversion Recovery Prepared Ultrashort Echo Time (STAIR-UTE) MRI Sequence in Multiple Sclerosis .
DOI: 10.
1148/radiol.
2020200425

Ya-Jun Ma , Hyungseok Jang , Zhao Wei , et al.
Myelin Imaging in Human Brain Using a Short Repetition Time Adiabatic Inversion Recovery Prepared Ultrashort Echo Time (STAIR-UTE) MRI Sequence in Multiple Sclerosis .
DOI: 10.
1148/radiol.
2020200425 10.
1148 /radiol.
2020200425 Leave a message here