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At this stage, functional nuclear magnetic resonance (fMRI) blood oxygen level-dependent (BOLD) signals have been widely used to assess neural activity based on intrinsic neuro-vascular coupling
Glioma progression disrupts the structural and functional integrity of the local cerebral vasculature through neovascularization, angiogenesis, remodeling of neurovascular units, and production of aberrant metabolites, ultimately altering the glioma vascular microenvironment
Recently, a study published in the journal Radiology investigated cerebral vascular dynamics and its correlation with tumor aggressiveness by using TSA and decision tree models of sLFO of resting-state BOLD signaling for early identification of glioma malignancy.
This retrospective study included 96 consecutive patients with histologically confirmed gliomas (March 2012 to February 2017)
A total of 88 glioma patients (WHO grade II, 45; grade III, 21; grade IV, 22; mean age, 42 years; age range, 20-73 years; 51 men) and from 1000 functional Forty healthy individuals (mean age, 32 years; age range, 24-49 years; 19 males) from the connectome project were included in the study
The present study demonstrates that gliomas induce vascular dysfunction near the tumor and hypersynchrony of vascular activity in the contralateral hemisphere, both of which are specific signs of malignancy
Original source:
Siqi Cai, Zhifeng Shi, Shihui Zhou, et al.
