Radiation therapy and immunotherapy improve tumor control

Personalized hyperfractionated stereotactic adaptive radiotherapy (PULSAR)-detailed content published in the International Journal of Radiation Oncology, Biology, Physics-by giving α-PD- during or after radiotherapy L1 treatment, with 10-day intervals instead of the traditional daily interval, achieves better tumor control

In the pulsar paradigm, patients receive only a small number of large doses of "pulses", which are transmitted through precise, image-guided precise transmissions at least one week or even several months apart

Dr.

By allowing more time to evaluate changes to meaningfully adapt to the process of individual patients, the PULSAR paradigm fulfills the promise of personalized cancer care

"Using artificial intelligence, the team can re-plan cancer treatment in 30 minutes instead of the usual 5 to 7 days," said Dr.

The collaborators of the PULSAR project are faculty from the Department of Radiation Oncology, Immunology, Pathology, and Neurosurgery, as well as members of the Peter O'Donnell Institute for Brain Research at UT Southwest University and the Simmons Cancer Center-the Simmons Cancer Center is One of the 51 comprehensive cancer centers designated by the National Cancer Institute, is a member of the National Comprehensive Cancer Network composed of 30 elite members, and its cancer projects rank among the top 25 in the country in US News and World Report

UTSW Radiation Oncology is the pioneer of PULSAR, with 71,000 square feet of radiation oncology service expansion with 7 new machines that can image tumors and perform radiation therapy

In the radiation oncology expansion plan, the new adaptive radiation therapy machine includes:

• Two Varian Ethos machines combine CT scanning, artificial intelligence and radiation therapy

  
  

• Two Elekta Unity machines, which combine MRI and radiotherapy

  
  

• Two Varian Halcyon machines, combining cone beam CT imaging and radiotherapy

  
  

• A RefleXion, which combines PET imaging and radiotherapy

  
  

Artificial intelligence experts from the Radiation Oncology and Lyda Hill Bioinformatics departments have developed machine learning algorithms, while radiation oncologists use the integrated radiation and imaging capabilities of the machine to make the treatment as precise as possible, hitting tumors without harming healthy tissues

Currently planning to share expertise and data with other academic institutions, including Massachusetts General Hospital in Boston (Massachusetts General Hospital)

discover

Dr.

They tested one of the most common immunotherapies, α-PD-L1 checkpoint inhibitors, and pulsar radiation, in this combination, like a vaccine for implanted tumors

In the pulsar paradigm, patients receive only a small number of large doses of "pulses", which are transmitted through precise, image-guided precise transmissions at least one week or even several months apart

Journal Reference :

1. Casey Moore, Ching-Cheng Hsu, Wei-Min Chen, Benjamin PC Chen, Chuanhui Han, Michael Story, Todd Aguilera, Laurentiu M.
   Pop, Raquibul Hannan, Yang-Xin Fu, Debabrata Saha, Robert Timmerman.
   Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR) in Preclinical Models Enhances Single-Agent Immune Checkpoint Blockade .
   International Journal of Radiation Oncology*Biology*Physics , 2021; 110 (5): 1306 DOI: 10.
   1016/j.
   ijrobp.
   2021.
   03.
   047